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533639 Pyruvate Dehydrogenase Kinase Inhibitor, AZD7545 - CAS 252017-04-2 - Calbiochem

Pyruvate Dehydrogenase Kinase Inhibitor, AZD7545, CAS 252017-04-2, is a potent, selective, reversible inhibitor of PDHK2 (IC₅₀ = 6.4 nM). Inhibits PDHK1 at higher levels (IC₅₀ = 36.8 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PDK Inhibitor, (R)-4-(3-Chloro-4-(3,3,3-trifluoro-2-hydroxy-2-methylpropanamido)phenylsulfonyl)-N,N-dimethylbenzamide, PDh Kinase Inhibitor, PDhK Inhibitor

Primary Target: pyruvate dehydrogenase kinases
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
252017-04-2C₁₉H₁₈ClF₃N₂O₅S

Products

Catalog NumberPackaging Qty/Pack
5.33639.0001 Glass bottle 5 mg
Description
OverviewA cell-permeable, bioavailable trifluomethylpropanamide compound that acts as a potent, selective, reversible, non-ATP-competitive inhibitor of pyruvate dehydrogenase kinases (IC50 = 36.8 & 6.4 nM for PDhK1 & PDhK2, respectively). Inhibits PDhK3 at much higher concentrations (IC50 = 600 nM) and robustly stimulates PDhK4 activity (> 10 nM). Also shown to increase pyruvate dehydrogenase (PDh) activity in liver and muscle, and potentiates pyruvate oxidation (EC50 = 105 nM in rat hepatocytes). Occupies lipoyl domain-binding site of PDhK2 (Kd = 19.2 nM) and disrupts the association of PDhK2 and inner lipoyl-bearing domain 2 of dihydrolipoyl acetyltransferase. Improves 24-h glucose profile and eliminates postparandial elevation in blood glucose in Zucker (fa/Fa) rats (10 mg/kg, b.i.d, p.o.,7 days).

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number533639
Brand Family Calbiochem®
SynonymsPDK Inhibitor, (R)-4-(3-Chloro-4-(3,3,3-trifluoro-2-hydroxy-2-methylpropanamido)phenylsulfonyl)-N,N-dimethylbenzamide, PDh Kinase Inhibitor, PDhK Inhibitor
References
ReferencesLi, J., et al. 2009. J. Biol. Chem. 284, 34458.
Tuganova, A., et al. 2007. Biochemistry 46, 8592.
Morrell, J.A., et al. 2003. Biochem. Soc. Trans. 31, 1168.
Mayers, R.M., et al. 2003. Biochem. Soc. Trans. 31, 1165.
Product Information
CAS number252017-04-2
FormWhite solid
Hill FormulaC₁₉H₁₈ClF₃N₂O₅S
Chemical formulaC₁₉H₁₈ClF₃N₂O₅S
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary Targetpyruvate dehydrogenase kinases
Primary Target IC<sub>50</sub>36.8 & 6.4 nM for PDhK1 & PDhK2, respectively
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
5.33639.0001 04055977287042

Documentation

Pyruvate Dehydrogenase Kinase Inhibitor, AZD7545 - CAS 252017-04-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Li, J., et al. 2009. J. Biol. Chem. 284, 34458.
Tuganova, A., et al. 2007. Biochemistry 46, 8592.
Morrell, J.A., et al. 2003. Biochem. Soc. Trans. 31, 1168.
Mayers, R.M., et al. 2003. Biochem. Soc. Trans. 31, 1165.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-September-2020 JSW
SynonymsPDK Inhibitor, (R)-4-(3-Chloro-4-(3,3,3-trifluoro-2-hydroxy-2-methylpropanamido)phenylsulfonyl)-N,N-dimethylbenzamide, PDh Kinase Inhibitor, PDhK Inhibitor
DescriptionA cell-permeable, bioavailable trifluomethylpropanamide compound that acts as a potent, selective, reversible, non-ATP-competitive inhibitor of pyruvate dehydrogenase kinases (IC50 = 36.8 & 6.4 nM for PDhK1 & PDhK2, respectively). Inhibits PDhK3 at much higher concentrations (IC50 = 600 nM) and robustly stimulates PDhK4 activity (> 10 nM). Also shown to increase pyruvate dehydrogenase (PDh) activity in liver and muscle, and potentiates pyruvate oxidation (EC50 = 105 nM in rat hepatocytes). Occupies lipoyl domain-binding site of PDhK2 (Kd = 19.2 nM) and disrupts the association of PDhK2 and inner lipoyl-bearing domain 2 of dihydrolipoyl acetyltransferase. Improves 24-h glucose profile and eliminates postparandial elevation in blood glucose in Zucker (fa/Fa) rats (10 mg/kg, b.i.d, p.o.,7 days).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number252017-04-2
Chemical formulaC₁₉H₁₈ClF₃N₂O₅S
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesLi, J., et al. 2009. J. Biol. Chem. 284, 34458.
Tuganova, A., et al. 2007. Biochemistry 46, 8592.
Morrell, J.A., et al. 2003. Biochem. Soc. Trans. 31, 1168.
Mayers, R.M., et al. 2003. Biochem. Soc. Trans. 31, 1165.