530389 Sigma-AldrichRIPK3 Inhibitor, GSKʹ872 - CAS 1346546-69-7 - Calbiochem
A cell-permeable, selective inhibitor of RIP3-selective kinase with >1,000-fold selectivity over a vast majority of more than 300 other kinases.
More>> A cell-permeable, selective inhibitor of RIP3-selective kinase with >1,000-fold selectivity over a vast majority of more than 300 other kinases. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: N-(6-(Isopropylsulfonyl)quinolin-4-yl)benzo[d]thiazol-5-amine, RIP3 Kinase Inhibitor I, Receptor-Interacting Protein Kinase 3 Inhibitor I, GSK-872, Necrosis Inhibitor V, RIPK3 Inhibitor I
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Overview
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Key Specifications Table
| CAS # | Empirical Formula |
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| 1346546-69-7 | C₁₉H₁₇N₃O₂S₂ |
Products
| Catalog Number | Packaging | Qty/Pack | |
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| 5.30389.0001 | Glass bottle | 10 mg |
| Description | |
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| Overview | A cell-permeable quinolinyl-benzothiazolamine compound that is reported to act as a RIP3-selective kinase inhibitor with >1,000-fold selectivity over a vast majority of more than 300 other kinases, including RIP1. RIP1 inhibitor Nec-1 (30 µM; Cat. Nos. 480065 & 505224) can be employed in conjunction with GSK'872 (3 µM) in delineating RIP1- vs. RIP3-dependency in Toll-like receptors- (TLRs) mediated necrosis and TNFR1-initiated necroptosis in the presence or absence of caspase inhibitor Z-VAD-FMK (25 µM; Cat. Nos. 627609 & 627610). |
| Catalogue Number | 530389 |
| Brand Family | Calbiochem® |
| Synonyms | N-(6-(Isopropylsulfonyl)quinolin-4-yl)benzo[d]thiazol-5-amine, RIP3 Kinase Inhibitor I, Receptor-Interacting Protein Kinase 3 Inhibitor I, GSK-872, Necrosis Inhibitor V, RIPK3 Inhibitor I |
| References | |
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| References | Kaiser, W.J., et al. 2013. J. Biol. Chem. 288, 31268. |
| Product Information | |
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| CAS number | 1346546-69-7 |
| Form | Yellow solid |
| Hill Formula | C₁₉H₁₇N₃O₂S₂ |
| Chemical formula | C₁₉H₁₇N₃O₂S₂ |
| Reversible | Y |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | RIP3 Kinase |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 5.30389.0001 | 04055977260762 |
Documentation
RIPK3 Inhibitor, GSKʹ872 - CAS 1346546-69-7 - Calbiochem SDS
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RIPK3 Inhibitor, GSKʹ872 - CAS 1346546-69-7 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 530389 |
References
| Reference overview |
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| Kaiser, W.J., et al. 2013. J. Biol. Chem. 288, 31268. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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