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553502 Rac1 Inhibitor - CAS 1177865-17-6 - Calbiochem

Rac1 Inhibitor, CAS 1177865-17-6, is a cell-permeable, reversible inhibitor of Rac1 GDP/GTP exchange. Interferes with the interaction between Rac1 and Rac-specific GEFs Trio and Tiam1 (IC₅₀ ~50 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NSC23766

Primary Target: Rac1
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
1177865-17-6C₂₄H₃₈Cl₃N₇

Products

Catalog NumberPackaging Qty/Pack
553502-10MG Glass bottle 10 mg
553502-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable pyrimidine compound that specifically and reversibly inhibits Rac1 GDP/GTP exchange activity by interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1 (IC50 ~50 µM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50 to 100 μM). Exhibits no effect on Cdc42 or RhoA activation and does not affect Rac1 interaction with BcrGAP or PAK1. Reduces TRAP-induced and collagen stimulated platelet aggregation (IC50 = 50 mM and 64 mM, respectively).
Catalogue Number553502
Brand Family Calbiochem®
SynonymsNSC23766
References
ReferencesDwivedi, S., et al. 2010. J. Translational Med. 8, 128.
Desire, L., et al. 2005. J. Biol. Chem. 280, 37516.
Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618.
Product Information
CAS number1177865-17-6
ATP CompetitiveN
FormLyophilized
Hill FormulaC₂₄H₃₈Cl₃N₇
Chemical formulaC₂₄H₃₈Cl₃N₇
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetRac1
Primary Target IC<sub>50</sub>~50 µM against Rac1 GDP/GTP exchange activity; 50 mM and 64 mM against TRAP-induced and collagen stimulated platelet aggregation
Purity≥93% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
553502-10MG 04055977193626
553502-5MG 07790788051433

Documentation

Rac1 Inhibitor - CAS 1177865-17-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Rac1 Inhibitor - CAS 1177865-17-6 - Calbiochem Certificates of Analysis

TitleLot Number
553502

References

Reference overview
Dwivedi, S., et al. 2010. J. Translational Med. 8, 128.
Desire, L., et al. 2005. J. Biol. Chem. 280, 37516.
Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618.

Brochure

Title
MAPK Pathway Poster ( 750 KB )

Citations

Title
  • Dwivedi, S., et al. 2010. J. Translational Med. 8, 128.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision28-February-2012 RFH
    SynonymsNSC23766
    DescriptionA cell-permeable pyrimidine compound that specifically and reversibly inhibits Rac1 GDP/GTP exchange activity by interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1 (IC50 ~50 µM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50 to 100 μM). Exhibits no effect on Cdc42 or RhoA activation and does not affect Rac1 interaction with BcrGAP or PAK1. Reduces TRAP-induced and collagen stimulated platelet aggregation (IC50 = 50 mM and 64 mM, respectively).
    FormLyophilized
    Intert gas (Yes/No) Packaged under inert gas
    CAS number1177865-17-6
    Chemical formulaC₂₄H₃₈Cl₃N₇
    Structure formulaStructure formula
    Purity≥93% by HPLC
    SolubilityH₂O (5 mg/ml)
    Storage Protect from light
    +2°C to +8°C
    Hygroscopic
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    Toxicity Carcinogenic / Teratogenic
    ReferencesDwivedi, S., et al. 2010. J. Translational Med. 8, 128.
    Desire, L., et al. 2005. J. Biol. Chem. 280, 37516.
    Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618.
    Citation
  • Dwivedi, S., et al. 2010. J. Translational Med. 8, 128.
    		•