553511 Sigma-AldrichRac1 Inhibitor II - CAS 1090893-12-1 - Calbiochem
The Rac1 Inhibitor II, also referenced under CAS 1090893-12-1, controls the biological activity of Rac1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The Rac1 Inhibitor II, also referenced under CAS 1090893-12-1, controls the biological activity of Rac1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 3-((3,5-Dimethylisoxazol-4-yl)methoxy)-N-(4-methyl-3-sulfamoyl-phenyl)benzamide, Z62954982
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Overview
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Key Specifications Table
| CAS # | Empirical Formula |
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| 1090893-12-1 | C₂₀H₂₁N₃O₅S |
Products
| Catalog Number | Packaging | Qty/Pack | |
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| 553511-10MG | 10 mg |
| Description | |
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| Overview | A cell-permeable isoxazolyl-benzamide compound that is more effective than NSC23766 (Cat. Nos. 553502 & 553508) in inhibiting PDGF-BB- (Cat. No. 521225) induced cellular Rac1 activation (45.8% vs 11.1% inhibition by 4 h pretreatment of the respective compound at 50 µM) in serum-starved SMCs (human aortic smooth muscle cells) by interfering Rac1-Tiam1 interaction, while exhibiting no effect toward cellular Cdc42 and RhoA activation or Rac1 interaction to its effector Pak1. Shown to effectively prevent PDGF-BB-induced membrane ruffling and lamellipodia formation in serum-starved 3T3 cells (4 h pretreatment at 25 µM). Also available in InSolution™ format (Cat. No. 553512). |
| Catalogue Number | 553511 |
| Brand Family | Calbiochem® |
| Synonyms | 3-((3,5-Dimethylisoxazol-4-yl)methoxy)-N-(4-methyl-3-sulfamoyl-phenyl)benzamide, Z62954982 |
| References | |
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| References | Ferri, N., et al. 2009. J. Med. Chem. 52, 4087. |
| Product Information | |
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| CAS number | 1090893-12-1 |
| Form | Off-white solid |
| Hill Formula | C₂₀H₂₁N₃O₅S |
| Chemical formula | C₂₀H₂₁N₃O₅S |
| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥93% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 553511-10MG | 04055977193701 |
Documentation
Rac1 Inhibitor II - CAS 1090893-12-1 - Calbiochem SDS
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Rac1 Inhibitor II - CAS 1090893-12-1 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 553511 |
References
| Reference overview |
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| Ferri, N., et al. 2009. J. Med. Chem. 52, 4087. |