531066 Sigma-AldrichRemodelin - CAS 1622921-15-6 - Calbiochem
A cell-permeable, potent, and stable analog of CPTH2 that restores nuclear shape and chromatin compactin in progeric fibroblasts.
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Synonyms: Cyclopentylidene-(4-(4-cyanophenyl)thiazol-2-yl)hydrazine, HBr, 4-(4-Chlorophenyl)-2-(2-cyclopentylidenehydrazinyl)thiazole, HBr, 4-(2-(2-Cyclopentylidenehydrazino)-1,3-thiazol-4-yl)benzonitrile, HBr
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Overview
| Replacement Information |
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Key Specifications Table
| CAS # | Empirical Formula |
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| 1622921-15-6 | C₁₅H₁₄N₄S • HBr |
Products
| Catalog Number | Packaging | Qty/Pack | |
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| 5.31066.0001 | Glass bottle | 25 mg |
| Description | |
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| Overview | A cell-permeable, potent, and stable analog of CPTH2 (Cat. No. 382111) that restores nuclear shape and chromatin compactin in AG11498 and AG06297 progeric fibroblasts from Hutchinson-Gilford progeria syndrome (HGPS) patients and in lamin A/C-depleted U2OS cells by inhibiting the activity of N-acetyltransferase 10 (NAT10; 10-50 µM). However, it does not affect non-laminopathic Werner syndrome cells. Improves DNA replication and enhances cell proliferation capacity. Also shown to prevent farnesyltransferase inhibitor-induced nuclear shape defects in normal fibroblasts and in U2OS cells and improves nuclear morphology in siLMNA (lamin A/C depletion by small interfering RNA transfection) treated cells. Does not affect Golgi apparatus integrity or tubulin polymer assembly and its effects are independent of mitosis. Please note that the molecular weight for this compound is batch-specific due to variable water content. |
| Catalogue Number | 531066 |
| Brand Family | Calbiochem® |
| Synonyms | Cyclopentylidene-(4-(4-cyanophenyl)thiazol-2-yl)hydrazine, HBr, 4-(4-Chlorophenyl)-2-(2-cyclopentylidenehydrazinyl)thiazole, HBr, 4-(2-(2-Cyclopentylidenehydrazino)-1,3-thiazol-4-yl)benzonitrile, HBr |
| References | |
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| References | Larrieu, D., et al. 2014. Science 344, 527. |
| Product Information | |
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| CAS number | 1622921-15-6 |
| Form | Tan powder |
| Hill Formula | C₁₅H₁₄N₄S • HBr |
| Chemical formula | C₁₅H₁₄N₄S • HBr |
| Hygroscopic | Hygroscopic |
| Reversible | Y |
| Quality Level | MQ100 |
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| Biological Information | |
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| Primary Target | NAT10 |
| Purity | ≥94% by HPLC |
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| Cell permeable | Y |
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| Safety Information according to GHS |
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| Safety Information |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 5.31066.0001 | 04055977242546 |
Documentation
Remodelin - CAS 1622921-15-6 - Calbiochem SDS
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References
| Reference overview |
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| Larrieu, D., et al. 2014. Science 344, 527. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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