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557502 Ro-20-1724 - CAS 29925-17-5 - Calbiochem

Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
29925-17-5C₁₅H₂₂N₂O₃

Products

Catalog NumberPackaging Qty/Pack
557502-100MG Plastic ampoule 100 mg
Description
OverviewA cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC50 = 2 µM). Inhibits superoxide generation and arachidonic-induced platelet aggregation. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells.
Catalogue Number557502
Brand Family Calbiochem®
Synonyms4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone
References
ReferencesDerian, C.K., et al. 1995. J. Immunol. 154, 308.
Rubin, L.L., et al. 1991. J. Cell Biol. 115, 1725.
Lad, P.M., et al. 1985. Biochim. Biophys. Acta 846, 286.
Bergstrand, H., et al. 1977. Mol. Pharmacol. 13, 38.
Product Information
CAS number29925-17-5
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₅H₂₂N₂O₃
Chemical formulaC₁₅H₂₂N₂O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPDE IV
Primary Target IC<sub>50</sub>2 µM against PDE IV
Purity≥98% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +15°C to +30°C
Do not freeze Ok to freeze
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
557502-100MG 04055977268119

Documentation

Ro-20-1724 - CAS 29925-17-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Ro-20-1724 - CAS 29925-17-5 - Calbiochem Certificates of Analysis

TitleLot Number
557502

References

Reference overview
Derian, C.K., et al. 1995. J. Immunol. 154, 308.
Rubin, L.L., et al. 1991. J. Cell Biol. 115, 1725.
Lad, P.M., et al. 1985. Biochim. Biophys. Acta 846, 286.
Bergstrand, H., et al. 1977. Mol. Pharmacol. 13, 38.

Citations

Title
  • Ryan W Carlin, et al. (2006) PVD9902, a porcine vas deferens epithelial cell line that exhibits neurotransmitter-stimulated anion secretion and expresses numerous HCO3- transporters. American Journal of Physiology Cell Physiology 290, C1560-C1571.
  • Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision09-September-2008 RFH
    Synonyms4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone
    DescriptionSelective inhibitor of cAMP-specific phosphodiesterase (PDE IV, IC50 = 2 µM). Inhibits superoxide generation and arachidonic-induced platelet aggregation. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells.
    FormWhite solid
    CAS number29925-17-5
    Chemical formulaC₁₅H₂₂N₂O₃
    Structure formulaStructure formula
    Purity≥98% by TLC
    SolubilityDMSO (20%) or ethanol (4%)
    Storage +15°C to +30°C
    Do Not Freeze Ok to freeze
    Toxicity Irritant
    ReferencesDerian, C.K., et al. 1995. J. Immunol. 154, 308.
    Rubin, L.L., et al. 1991. J. Cell Biol. 115, 1725.
    Lad, P.M., et al. 1985. Biochim. Biophys. Acta 846, 286.
    Bergstrand, H., et al. 1977. Mol. Pharmacol. 13, 38.
    Citation
  • Ryan W Carlin, et al. (2006) PVD9902, a porcine vas deferens epithelial cell line that exhibits neurotransmitter-stimulated anion secretion and expresses numerous HCO3- transporters. American Journal of Physiology Cell Physiology 290, C1560-C1571.