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557525 Ro-32-0432 - CAS 145333-02-4 - Calbiochem

A selective cell-permeable protein kinase C inhibitor.

Ro-32-0432 - CAS 145333-02-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-{8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl}-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide XI, HCl, 3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-y1)-4-(1-methyl-1H-indol-3-y1)-1H-pyrrole-2,5-dione hydrochloride

Primary Target: PKCα
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
145333-02-4C₂₈H₂₈N₄O₂ · HCl

Products

Catalog NumberPackaging Qty/Pack
557525-1MG Plastic ampoule 1 mg
Description
OverviewA selective cell-permeable protein kinase C inhibitor. Displays about 10-fold greater selectivity for PKCα (IC50 = 9 nM) and 4-fold greater selectivity for PKCβI (IC50 = 28 nM) over PKCε (IC50 = 108 nM). Also prevents T cell-driven chronic inflammatory responses in vivo.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number557525
Brand Family Calbiochem®
Synonyms2-{8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl}-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide XI, HCl, 3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-y1)-4-(1-methyl-1H-indol-3-y1)-1H-pyrrole-2,5-dione hydrochloride
References
ReferencesBirchall, A.M., et al. 1994. J. Pharmacol. Exp. Ther. 268, 922.
Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.
Product Information
CAS number145333-02-4
ATP CompetitiveN
FormRed solid
Hill FormulaC₂₈H₂₈N₄O₂ · HCl
Chemical formulaC₂₈H₂₈N₄O₂ · HCl
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPKCα
Primary Target IC<sub>50</sub>9 nM, 28 nM, 108 nM, against PKCα, PKCβI, and PKCε, respectively
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
557525-1MG 04055977193008

Documentation

Ro-32-0432 - CAS 145333-02-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Ro-32-0432 - CAS 145333-02-4 - Calbiochem Certificates of Analysis

TitleLot Number
557525

References

Reference overview
Birchall, A.M., et al. 1994. J. Pharmacol. Exp. Ther. 268, 922.
Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.

Brochure

Title
PKC Pathway Poster PDF ( 676 KB )

Citations

Title
  • Felicity J. Ashcroft, et al. (2004) Control of expression of the lectin-like protein Reg-1 by gastrin: role of the Rho family GTPase RhoA and a C-rich promoter element. Biochemical Journal 381, 397-403.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision22-October-2014 JSW
    Synonyms2-{8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl}-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide XI, HCl, 3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-y1)-4-(1-methyl-1H-indol-3-y1)-1H-pyrrole-2,5-dione hydrochloride
    DescriptionA selective cell-permeable protein kinase C inhibitor. Displays about a 10-fold greater selectivity for PKCα (IC50 = 9 nM) and a 4-fold greater selectivity for PKCβI (IC50 = 28 nM) over PKCε (IC50 = 108 nM). Also prevents T-cell driven chronic inflammatory responses in vivo.
    FormRed solid
    CAS number145333-02-4
    Chemical formulaC₂₈H₂₈N₄O₂ · HCl
    Structure formulaStructure formula
    Purity≥98% by HPLC
    SolubilityDMSO (5 mg/ml)
    Storage Protect from light
    +2°C to +8°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
    Toxicity Standard Handling
    ReferencesBirchall, A.M., et al. 1994. J. Pharmacol. Exp. Ther. 268, 922.
    Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.
    Citation
  • Felicity J. Ashcroft, et al. (2004) Control of expression of the lectin-like protein Reg-1 by gastrin: role of the Rho family GTPase RhoA and a C-rich promoter element. Biochemical Journal 381, 397-403.
    		•