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559418 SBHA - CAS 38937-66-5 - Calbiochem

A cell-permeable bishydroxamic acid histone deacetylase (HDAC) inhibitor with anti-tumor properties.

SBHA - CAS 38937-66-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Suberic Bishydroxamate, Suberoyl Bishydroxamic Acid, HDAC Inhibitor XII

Primary Target: human HDAC1 and HDAC3 activities
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
38937-66-5C₈H₁₆N₂O₄

Products

Catalog NumberPackaging Qty/Pack
559418-100MG Plastic ampoule 100 mg
Description
OverviewA cell-permeable bishydroxamic acid histone deacetylase (HDAC) inhibitor with anti-tumor properties. Causes an increase in acetylated histone H4 in MEL cells and inhibits the human HDAC1 and HDAC3 activities with a similar potency (ID50 ~ 250-300 nM). Belongs to the hybrid polar class of compounds that acts both as inducers of differentiation of transformed cells and apoptosis. Suppresses the growth of proliferating keratinocytes and squamous cell carcinoma cells (IC50 = 11.57 µM and 5.39 µM, respectively).
Catalogue Number559418
Brand Family Calbiochem®
SynonymsSuberic Bishydroxamate, Suberoyl Bishydroxamic Acid, HDAC Inhibitor XII
References
ReferencesBrinkmann, H., et al. 2001. J. Biol. Chem. 276, 22491.
Richon, V.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 3003.
Richon, V.M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 5705.
Marks, P.A., 1994. Proc. Natl. Acad. Sci. USA 91, 10251.
Product Information
CAS number38937-66-5
ATP CompetitiveN
DeclarationNot available for sale in the United States.
FormWhite solid
Hill FormulaC₈H₁₆N₂O₄
Chemical formulaC₈H₁₆N₂O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targethuman HDAC1 and HDAC3 activities
Primary Target IC<sub>50</sub>11.57 µM and 5.39 µM in suppressing the growth of proliferating keratinocytes and squamous cell carcinoma cells, respectively
Purity≥95% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.


From Catalog:
Desc. Field- added "cell-permeable
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
559418-100MG 04055977268171

Documentation

SBHA - CAS 38937-66-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

SBHA - CAS 38937-66-5 - Calbiochem Certificates of Analysis

TitleLot Number
559418

References

Reference overview
Brinkmann, H., et al. 2001. J. Biol. Chem. 276, 22491.
Richon, V.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 3003.
Richon, V.M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 5705.
Marks, P.A., 1994. Proc. Natl. Acad. Sci. USA 91, 10251.

Technical Info

Title
White Paper - The Message in the Marks: Deciphering Cancer Epigenetics
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-September-2021 JSW
SynonymsSuberic Bishydroxamate, Suberoyl Bishydroxamic Acid, HDAC Inhibitor XII
DescriptionA cell-permeable bishydroxamic acid histone deacetylase (HDAC) inhibitor with anti-tumor properties. Reported to cause an increase in acetylated histone H4 in MEL cells. Also reported to inhibit human HDAC1 and HDAC3 activities with a similar potency (ID50 ~ 250-300 nM). Belongs to the hybrid polar class of compounds that induce both differentiation of transformed cells and apoptosis. Shown to suppress the growth of proliferating keratinocytes and squamous cell carcinoma cells (IC50 = 11.57 µM and 5.39 µM, respectively).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number38937-66-5
Chemical formulaC₈H₁₆N₂O₄
Structure formulaStructure formula
Purity≥95% by TLC
SolubilityDMSO (10 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.


From Catalog:
Desc. Field- added "cell-permeable
Toxicity Standard Handling
ReferencesBrinkmann, H., et al. 2001. J. Biol. Chem. 276, 22491.
Richon, V.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 3003.
Richon, V.M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 5705.
Marks, P.A., 1994. Proc. Natl. Acad. Sci. USA 91, 10251.