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566331 SIRT2 Inhibitor II, AK-1 - CAS 330461-64-8 - Calbiochem

The SIRT2 Inhibitor II, AK-1, also referenced under CAS 330461-64-8, controls the biological activity of SIRT2. This small molecule/inhibitor is primarily used for Cell Structure applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(azepan-1-ylsulfonyl)-N-(3-nitrophenyl)benzamide, SIRT2 Inhibitor II, AK-1

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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
330461-64-8C₁₉H₂₁N₃O₅S

Products

Catalog NumberPackaging Qty/Pack
566331-10MG Glass bottle 10 mg
Description
OverviewA cell permeable, benzylsulfonamide that inhibits SIRT2 activity (IC50= 12.5 µM through enzymatic assay) by targeting the SIRT2 nicotinamide binding site, but may also target SIRT1 and SIRT3 (IC50 >40 µM) with much less potency. Western analysis illustrates that treatment with AK-1 (> 25 µM) leads to an increase in acetylated tubulin. AK-1 (1 to 10 µM) is shown to rescue neuronal dysfunction in two in vivo models of Huntington's Disease (HD) in Dropshila and Caenorhabditis elegans. It also demonstrates recovery of neuronal toxicity in a primary model of HD from 1µM to 4 µM similar to that of genetic SIRT2 inhibition, and also correlates with the negative regulation of sterol biosynthesis.
Catalogue Number566331
Brand Family Calbiochem®
Synonyms3-(azepan-1-ylsulfonyl)-N-(3-nitrophenyl)benzamide, SIRT2 Inhibitor II, AK-1
References
ReferencesLuthi-Carter, R., et al. 2010. Proc. Natl. Acad. Sci. 107, 7927.
Outeiro, TF., et al. 2007. Science 317, 516.
Product Information
CAS number330461-64-8
FormOff-white solid
Hill FormulaC₁₉H₂₁N₃O₅S
Chemical formulaC₁₉H₂₁N₃O₅S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity>95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
566331-10MG 04055977191479

Documentation

SIRT2 Inhibitor II, AK-1 - CAS 330461-64-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

SIRT2 Inhibitor II, AK-1 - CAS 330461-64-8 - Calbiochem Certificates of Analysis

TitleLot Number
566331

References

Reference overview
Luthi-Carter, R., et al. 2010. Proc. Natl. Acad. Sci. 107, 7927.
Outeiro, TF., et al. 2007. Science 317, 516.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-December-2013 JSW
Synonyms3-(azepan-1-ylsulfonyl)-N-(3-nitrophenyl)benzamide, SIRT2 Inhibitor II, AK-1
DescriptionA cell permeable, benzylsulfonamide that inhibits SIRT2 activity (IC50= 12.5 µM through enzymatic assay) by targeting the SIRT2 nicotinamide binding site, but may also target SIRT1 and SIRT3 (IC50 >40 µM) with much less potency. Western analysis illustrates that treatment with AK-1 (> 25 µM) leads to an increase in acetylated tubulin. AK-1 (1 to 10 µM) is shown to rescue neuronal dysfunction in two in vivo models of Huntington's Disease (HD) in Dropshila and Caenorhabditis elegans. It also demonstrates recovery of neuronal toxicity in a primary model of HD from 1µM to 4 µM similar to that of genetic SIRT2 inhibition, and also correlates with the negative regulation of sterol biosynthesis.
FormOff-white solid
CAS number330461-64-8
Chemical formulaC₁₉H₂₁N₃O₅S
Structure formulaStructure formula
Purity>95% by HPLC
SolubilityDMSO (50 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesLuthi-Carter, R., et al. 2010. Proc. Natl. Acad. Sci. 107, 7927.
Outeiro, TF., et al. 2007. Science 317, 516.