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Key Documents

566326

Sigma-Aldrich

SIRT2 Inhibitor, Inactive Control, AGK7

The SIRT2 Inhibitor, Inactive Control, AGK7, also referenced under CAS 304896-21-7, controls the biological activity of SIRT2. This small molecule/inhibitor is primarily used for Cell Structure applications.

Synonym(s):

SIRT2 Inhibitor, Inactive Control, AGK7, SIRT2 Inhibitor I, Inactive Control

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About This Item

Empirical Formula (Hill Notation):
C23H13Cl2N3O2
CAS Number:
Molecular Weight:
434.27
UNSPSC Code:
12352200

Quality Level

Assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C23H13Cl2N3O2/c24-16-6-8-19(25)18(12-16)21-9-7-17(30-21)11-15(13-26)23(29)28-20-5-1-3-14-4-2-10-27-22(14)20/h1-12H,(H,28,29)

InChI key

WRDKBSLEHFRKGG-UHFFFAOYSA-N

General description

A cell-permeable structural isomer of SIRT2 Inhibitor, AGK2 (Cat. No. 566324) that selectively inhibits sirtuin 3 over sirtuins 1 and 2 (IC50 = >5 µM, >50 µM and >50 µM for SIRT3, SIRT1 and SIRT2, respectively) and poorly affects both α-synuclein-mediated toxicity and α-Syn aggregation in α-Syn-H4 cells.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Sirtuin 3
Product does not compete with ATP.
Reversible: no
Target IC50: >5 µM, >50 µM and >50 µM for SIRT3, SIRT1 and SIRT2

Packaging

Packaged under inert gas

Warning

Toxicity: Regulatory Review (Z)

Other Notes

Outerio, T.F., et al. 2007. Science317, 516.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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