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567417 SOD1 Inhibitor, LCS-1 - CAS 41931-13-9 - Calbiochem

Overview

Key Specifications Table

CAS #Empirical Formula
41931-13-9C₁₁H₈Cl₂N₂O

Products

Catalog NumberPackaging Qty/Pack
567417-10MG Glass bottle 10 mg
Description
OverviewA 2-phenylpyridazin-3(2H)-one based non-copper chelater that selectively inhibits the activity of Superoxide dismutase 1 (Cu/Zn-SOD) (IC50 = 1.07 µM). Cells over-expressing SOD1 show reduced sensitivity to LCS-1. Shown to preferably inhibit the growth of a variety of human lung adenocarinoma cell lines with EGFR and KRAS mutations (IC50 = 200 nM). Prevents serum-induced activation of the ERK and PI 3-kinase/AKT signaling thereby affecting cell growth and survival. Apparent half-life of this compound is reported to be 6.6 min in human liver microsomes.
Catalogue Number567417
Brand Family Calbiochem®
Synonymslung cancer screen 1, 4,5-dichloro-2-m-tolylpyridazin-3(2H)-one, 4,5-dichloro-2-(3-methylphenyl)-3(2H)-pyridazinone, Superoxide dismutase 1 inhibitor
References
ReferencesSomwar, R., et al. 2011, PNAS in press.
Somwar, R., et al. 2009. J. Biomol. Screen 14, 1176
Product Information
CAS number41931-13-9
FormWhite solid
Hill FormulaC₁₁H₈Cl₂N₂O
Chemical formulaC₁₁H₈Cl₂N₂O
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥99% by HPLC
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalog Number GTIN
567417-10MG 04055977267242