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Buffer Detection Kit for Magnetic Beads
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567417
Sigma-AldrichSOD1 Inhibitor, LCS-1 - CAS 41931-13-9 - Calbiochem
The SOD1 Inhibitor, LCS-1, also referenced under CAS 41931-13-9, controls the biological activity of SOD1.
More>>The SOD1 Inhibitor, LCS-1, also referenced under CAS 41931-13-9, controls the biological activity of SOD1. Less<<
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
A 2-phenylpyridazin-3(2H)-one based non-copper chelater that selectively inhibits the activity of Superoxide dismutase 1 (Cu/Zn-SOD) (IC50 = 1.07 µM). Cells over-expressing SOD1 show reduced sensitivity to LCS-1. Shown to preferably inhibit the growth of a variety of human lung adenocarinoma cell lines with EGFR and KRAS mutations (IC50 = 200 nM). Prevents serum-induced activation of the ERK and PI 3-kinase/AKT signaling thereby affecting cell growth and survival. Apparent half-life of this compound is reported to be 6.6 min in human liver microsomes.
Catalogue Number
567417
Brand Family
Calbiochem®
Synonyms
lung cancer screen 1, 4,5-dichloro-2-m-tolylpyridazin-3(2H)-one, 4,5-dichloro-2-(3-methylphenyl)-3(2H)-pyridazinone, Superoxide dismutase 1 inhibitor
References
References
Somwar, R., et al. 2011, PNAS in press. Somwar, R., et al. 2009. J. Biomol. Screen14, 1176
SOD1 Inhibitor, LCS-1 - CAS 41931-13-9 - Calbiochem Certificates of Analysis
Title
Lot Number
567417
References
Reference overview
Somwar, R., et al. 2011, PNAS in press. Somwar, R., et al. 2009. J. Biomol. Screen14, 1176
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
27-June-2012 JSW
Synonyms
lung cancer screen 1, 4,5-dichloro-2-m-tolylpyridazin-3(2H)-one, 4,5-dichloro-2-(3-methylphenyl)-3(2H)-pyridazinone, Superoxide dismutase 1 inhibitor
Description
A 2-phenylpyridazin-3(2H)-one based non-copper chelater that selectively inhibits the activity of Superoxide dismutase 1 (Cu/Zn-SOD) (IC50 = 1.07 µM). Cells over-expressing SOD1 show reduced sensitivity to LCS-1. Shown to preferably inhibit the growth of a variety of human lung adenocarinoma cell lines with EGFR and KRAS mutations (IC50 = 200 nM). Prevents serum-induced activation of the ERK and PI 3-kinase/AKT signaling thereby affecting cell growth and survival. Apparent half-life of this compound is reported to be 6.6 min in human liver microsomes.
Form
White solid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
41931-13-9
Chemical formula
C₁₁H₈Cl₂N₂O
Structure formula
Purity
≥99% by HPLC
Solubility
DMSO (50 mg/mlg; clear, colorless solution)
Storage
Protect from light
-20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Somwar, R., et al. 2011, PNAS in press. Somwar, R., et al. 2009. J. Biomol. Screen14, 1176