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407625 STAT3 Inhibitor XVI - CAS 1260364-43-9 - Calbiochem

The STAT3 Inhibitor XVI controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: IL-6 Inhibitor

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407625
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
1260364-43-9C₂₁H₂₂N₂O₃S₃

Products

Catalog NumberPackaging Qty/Pack
407625-5MG Glass bottle 5 mg
Description
OverviewA cell-permeable, arylsulphonamidyl thiophene amide that is shown to reduce IL-6-induced STAT3 transcriptional activity (EC50 = 15 µM) in a luciferase reporter assay, in HeLa cells. It selectively inhibits STAT3, but not STAT1, phosphorylation following IL-6 stimulation in both HeLa and MDA-MB-231 breast cancer cells at concentrations of 10-30 µ:M and 30-100 µM, respectively. Following IL-6 stimulation, it suppresses the cell viability of STAT3-dependent cancer cells by 40% compared with that of STAT3-null cancer cells at the low micromolar level.
Catalogue Number407625
Brand Family Calbiochem®
SynonymsIL-6 Inhibitor
References
ReferencesZinzalla, G., et al. 2010. Bioorg Med Chem Lett 20, 7029.
Product Information
CAS number1260364-43-9
FormGrey solid
Hill FormulaC₂₁H₂₂N₂O₃S₃
Chemical formulaC₂₁H₂₂N₂O₃S₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Regulatory Review
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
407625-5MG 04055977211382

Documentation

STAT3 Inhibitor XVI - CAS 1260364-43-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

STAT3 Inhibitor XVI - CAS 1260364-43-9 - Calbiochem Certificates of Analysis

TitleLot Number
407625

References

Reference overview
Zinzalla, G., et al. 2010. Bioorg Med Chem Lett 20, 7029.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-April-2012 JSW
SynonymsIL-6 Inhibitor
DescriptionA cell-permeable, arylsulphonamidyl thiophene amide that is shown to reduce IL-6-induced STAT3 transcriptional activity (EC50 = 15 µM) in a luciferase reporter assay, in HeLa cells. It selectively inhibits STAT3, but not STAT1, phosphorylation following IL-6 stimulation in both HeLa and MDA-MB-231 breast cancer cells at concentrations of 10-30 µ:M and 30-100 µM, respectively. Following IL-6 stimulation, it suppresses the cell viability of STAT3-dependent cancer cells by 40% compared with that of STAT3-null cancer cells at the low micromolar level.
FormGrey solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1260364-43-9
Chemical formulaC₂₁H₂₂N₂O₃S₃
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml; light pink/purple solution)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Regulatory Review
ReferencesZinzalla, G., et al. 2010. Bioorg Med Chem Lett 20, 7029.