Millipore Sigma Vibrant Logo
Attention: We have moved. EMD Millipore products are no longer available for purchase on emdmillipore.com.Learn More

572660 SU11652 - CAS 326914-10-7 - Calbiochem

A cell-permeable pyrrole-indolinone compound that acts as a potent, reversible, and ATP-competitive tyrosine kinase receptor and angiogenic inhibitor.

SU11652 - CAS 326914-10-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-[(Z)-(5-Chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-[2-(diethylamino)ethyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, VEGFR Tyrosine Kinase Inhibitor XVII, VEGFR2 Kinase Inhibitor XIV, PDGFR Tyrosine Kinase Inhibitor VIII

Primary Target: PDGFRB
View Products on Sigmaaldrich.com
572660
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
326914-10-7C₂₂H₂₇ClN₄O₂

Products

Catalog NumberPackaging Qty/Pack
572660-500UG Plastic ampoule 500 μg
Description
OverviewA cell-permeable pyrrole-indolinone compound that acts as a potent, reversible, and ATP-competitive tyrosine kinase receptor and angiogenic inhibitor that exhibits greater selectivity for PDGFRβ (IC50 = 3 nM), VEGFR2 (IC50 = 27 nM), FGFR1 (IC50 = 170 nM), and Kit family members (IC50 = ~ 10-500 nM) over EGFR (IC50 >20 µM). Reported to display anti-proliferative and pro-apoptotic properties in tumor cells.
Catalogue Number572660
Brand Family Calbiochem®
Synonyms5-[(Z)-(5-Chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-[2-(diethylamino)ethyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, VEGFR Tyrosine Kinase Inhibitor XVII, VEGFR2 Kinase Inhibitor XIV, PDGFR Tyrosine Kinase Inhibitor VIII
References
ReferencesHeryanto, B., et al. 2003. Reproduction 125, 334.
Sun, L., et al. 2003. J. Med. Chem. 46, 1116.
Liao, A.T., et al. 2002. Blood 100, 585.
Product Information
CAS number326914-10-7
ATP CompetitiveY
FormOrange powder
Hill FormulaC₂₂H₂₇ClN₄O₂
Chemical formulaC₂₂H₂₇ClN₄O₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPDGFRB
Primary Target IC<sub>50</sub>3 nM, 27 nM, 170 nM against PDGFRβ, VEGFR2, and FGFR1, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
572660-500UG 04055977266320

Documentation

SU11652 - CAS 326914-10-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

SU11652 - CAS 326914-10-7 - Calbiochem Certificates of Analysis

TitleLot Number
572660

References

Reference overview
Heryanto, B., et al. 2003. Reproduction 125, 334.
Sun, L., et al. 2003. J. Med. Chem. 46, 1116.
Liao, A.T., et al. 2002. Blood 100, 585.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision24-September-2010 JSW
Synonyms5-[(Z)-(5-Chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-[2-(diethylamino)ethyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, VEGFR Tyrosine Kinase Inhibitor XVII, VEGFR2 Kinase Inhibitor XIV, PDGFR Tyrosine Kinase Inhibitor VIII
DescriptionA cell-permeable, potent, reversible, and ATP-competitive inhibitor of tyrosine kinase activity of PDGFRβ (IC50 = 3 nM), VEGFR2 (IC50 = 27 nM), FGFR1 (IC50 = 170 nM), and Kit family members (IC50 ~10-500 nM). Does not effect the activity of EGFR (IC50 >20 µM). Reported to display anti-proliferative, antiangiogenic and pro-apoptotic properties in tumor cells.
FormOrange powder
Intert gas (Yes/No) Packaged under inert gas
CAS number326914-10-7
Chemical formulaC₂₂H₂₇ClN₄O₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (4 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesHeryanto, B., et al. 2003. Reproduction 125, 334.
Sun, L., et al. 2003. J. Med. Chem. 46, 1116.
Liao, A.T., et al. 2002. Blood 100, 585.