566224 Sigma-AldrichSialyltransferase Inhibitor, 3Fax-Peracetyl Neu5Ac - Calbiochem
Sialyltransferase Inhibitor, 3Fax-Peracetyl Neu5Ac, is a cell-permeable sialylic acid analog that is converted to a CMP-Neu5Ac and inhibits sialyltransferase.
More>> Sialyltransferase Inhibitor, 3Fax-Peracetyl Neu5Ac, is a cell-permeable sialylic acid analog that is converted to a CMP-Neu5Ac and inhibits sialyltransferase. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: (1S,2R)-1-((3S,4R,5R,6S)-3-acetamido-4,6-diacetoxy-5-fluoro-6-(methoxycarbonyl)tetrahydro-2H-pyran-2-yl)propane-1,2,3-triyl triacetate, 3Fax-Neu5Ac Prodrug
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Overview
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Key Specifications Table
| Empirical Formula |
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| C₂₂H₃₀FNO₁₄ |
Products
| Catalog Number | Packaging | Qty/Pack | |
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| 566224-10MG | Glass bottle | 10 mg |
| Description | |
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| Overview | A cell-permeable sialylic acid analog that upon cellular uptake is transformed into a CMP-Neu5Ac (Cat. No. 233264) mimetic bearing a C3 fluorine substituent at the axial position, effectively inhibiting sialyltransferase in a donor substrate CMP-Neu5Ac-competitive manner. Shown to effectively abloishes HL-60 cell surface SLeX expression (by >95%; 200 µM for 5 days), resulting in dramatic reductions in cell surface E-selectin and P-selectin binding (by >95% and >80%, respectively), without affecting cell viability or proliferation. |
| Catalogue Number | 566224 |
| Brand Family | Calbiochem® |
| Synonyms | (1S,2R)-1-((3S,4R,5R,6S)-3-acetamido-4,6-diacetoxy-5-fluoro-6-(methoxycarbonyl)tetrahydro-2H-pyran-2-yl)propane-1,2,3-triyl triacetate, 3Fax-Neu5Ac Prodrug |
| References | |
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| References | Rillahan, C., et al. 2012. Nat. Chem. Bio. 8, 661. |
| Product Information | |
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| Form | White solid |
| Hill Formula | C₂₂H₃₀FNO₁₄ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications | |
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| Application | Sialyltransferase Inhibitor, 3Fax-Peracetyl Neu5Ac, is a cell-permeable sialylic acid analog that is converted to a CMP-Neu5Ac and inhibits sialyltransferase. |
| Biological Information | |
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| Primary Target | Sialyltransferase |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Toxicological Information |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 566224-10MG | 04055977191332 |
Documentation
Sialyltransferase Inhibitor, 3Fax-Peracetyl Neu5Ac - Calbiochem SDS
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Sialyltransferase Inhibitor, 3Fax-Peracetyl Neu5Ac - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 566224 |
References
| Reference overview |
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| Rillahan, C., et al. 2012. Nat. Chem. Bio. 8, 661. |