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567020 Simvastatin - CAS 79902-63-9 - Calbiochem

A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation.

Simvastatin - CAS 79902-63-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: MK-733, L-Type Calcium Channel Blocker VI

Primary Target: farnesylation
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
79902-63-9C₂₅H₃₈O₅

Products

Catalog NumberPackaging Qty/Pack
567020-50MG Plastic ampoule 50 mg
Description
OverviewA lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca2+ signaling and insulin secretion by blocking L-type Ca2+ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. Note: this product is supplied in an inactive form and requires treatment with NaOH in EtOH followed by neutralization to pH 7.2 for activation.
Catalogue Number567020
Brand Family Calbiochem®
SynonymsMK-733, L-Type Calcium Channel Blocker VI
References
ReferencesYada, T., et al. 1999. Br. J. Pharmacol. 126, 1205.
Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522.
Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87.
Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259.
Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016.
Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
Product Information
CAS number79902-63-9
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₂₅H₃₈O₅
Chemical formulaC₂₅H₃₈O₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetfarnesylation
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
ContaminantsHeavy metals: <20 ppm
Heavy metals≤20 ppm
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSEK7798000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution in ethanol-NaOH, aliquot and freeze (-20°C) Ethanol-NaOH solutions are stable for up to 1 month at -20°C. Neutralized solutions should be used immediately.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
567020-50MG 04055977267099

Documentation

Simvastatin - CAS 79902-63-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Simvastatin - CAS 79902-63-9 - Calbiochem Certificates of Analysis

TitleLot Number
567020

References

Reference overview
Yada, T., et al. 1999. Br. J. Pharmacol. 126, 1205.
Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522.
Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87.
Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259.
Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016.
Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-May-2008 RFH
SynonymsMK-733, L-Type Calcium Channel Blocker VI
DescriptionA lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca2+-signaling and insulin secretion by blocking L-type Ca2+ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. Note: This product is supplied in an inactive form and requires treatment with NaOH in ethanol followed by neutralization to pH 7.2 for activation.
FormOff-white solid
CAS number79902-63-9
RTECSEK7798000
Chemical formulaC₂₅H₃₈O₅
Structure formulaStructure formula
Purity≥98% by HPLC
ContaminantsHeavy metals: <20 ppm
SolubilityDMSO or Ethanol (50 mg/ml). Dissolve 50 mg in 1 ml in ethanol and add 0.813 ml of 1N NaOH. Adjust the pH to 7.2 by adding small quantities of 1N HCl before use.
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution in ethanol-NaOH, aliquot and freeze (-20°C) Ethanol-NaOH solutions are stable for up to 1 month at -20°C. Neutralized solutions should be used immediately.
Toxicity Standard Handling
Merck USA index14, 8539
ReferencesYada, T., et al. 1999. Br. J. Pharmacol. 126, 1205.
Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522.
Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87.
Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259.
Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016.
Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.