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567565 Sodium Stibogluconate - CAS 16037-91-5 - Calbiochem

Sodium Stibogluconate, CAS 16037-91-5, is a pentavalent antimony compound that irreversibly inhibits protein tyrosine phosphatase activity, including SHP-1, by forming a stable complex.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: SSG, Antimony Sodium Gluconate, NaSbv, PTP Inhibitor XXIV, SHP1 Inhibitor IV

Primary Target: PTPase activity, including Src homology PTPase-1 (SHP-1)
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
16037-91-5C₁₂H₁₇O₁₇Sb₂ · 3Na · 9H₂O

Products

Catalog NumberPackaging Qty/Pack
567565-1GM Plastic ampoule 1 gm
Description
OverviewA pentavalent antimony compound that irreversibly inhibits protein tyrosine phosphatase (PTPase) activity, including Src homology PTPase-1 (SHP-1) (99% inhibition at ~11 µM) by forming a stable complex. At higher concentrations (~110 µM), it inhibits SHP-2 and PTP1B activities.
Catalogue Number567565
Brand Family Calbiochem®
SynonymsSSG, Antimony Sodium Gluconate, NaSbv, PTP Inhibitor XXIV, SHP1 Inhibitor IV
References
ReferencesWortmann, G., et al. 2002. Clin. Infect. Dis. 35, 261.
Pathak, M.K. and Yi, T. 2001. J. Immunol. 167, 3391.
Product Information
CAS number16037-91-5
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₂H₁₇O₁₇Sb₂ · 3Na · 9H₂O
Chemical formulaC₁₂H₁₇O₁₇Sb₂ · 3Na · 9H₂O
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationSodium Stibogluconate, CAS 16037-91-5, is a pentavalent antimony compound that irreversibly inhibits protein tyrosine phosphatase activity, including SHP-1, by forming a stable complex.
Biological Information
Primary TargetPTPase activity, including Src homology PTPase-1 (SHP-1)
Primary Target IC<sub>50</sub>~11 µM causing 99% inhibition of protein tyrosine phosphatase (PTPase) activity, including Src homology PTPase-1 (SHP-1)
Purity≥90% by titration on dry basis (≥30% Sb content)
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsUnstable in solution; reconstitute just prior to use.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
567565-1GM 07790788051648

Documentation

Sodium Stibogluconate - CAS 16037-91-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Sodium Stibogluconate - CAS 16037-91-5 - Calbiochem Certificates of Analysis

TitleLot Number
567565

References

Reference overview
Wortmann, G., et al. 2002. Clin. Infect. Dis. 35, 261.
Pathak, M.K. and Yi, T. 2001. J. Immunol. 167, 3391.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-June-2008 RFH
SynonymsSSG, Antimony Sodium Gluconate, NaSbv, PTP Inhibitor XXIV, SHP1 Inhibitor IV
DescriptionA pentavalent antimony compound that forms a stable complex with and irreversibly inhibits Src homology protein tyrosine phosphatase (SHP-1) (99% inhibition at 11 µM). Also inhibits SHP-2 and PTP1B at an ~10-fold higher concentration (~110 µM). Does not inhibit the dual specificity protein tyrosine phosphatase (PTPase) or mitogen-activated protein kinase phosphatase-1 (MKP-1). Reported to induce general protein tyrosine phosphorylation and enhance IL-3-induced protein tyrosine phosphorylation of Jak2 and Stat5 in Baf3 cells. Also reported to augment IL-3-induced proliferation in Baf3 cells (ECmax = 44 µM) and GM-CSF-induced proliferation in TF-1 cells (ECmax = 55 µM). Exhibits anti-leishmanial effects.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number16037-91-5
Chemical formulaC₁₂H₁₇O₁₇Sb₂ · 3Na · 9H₂O
Structure formulaStructure formula
Purity≥90% by titration on dry basis (≥30% Sb content)
SolubilityH₂O (1 mg/ml). Heating to 75°C with constant stirring or constant stirring overnight at room temperature may be required for complete solubilization.
Storage Protect from moisture
Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsUnstable in solution; reconstitute just prior to use.
Toxicity Standard Handling
Merck USA index14, 701
ReferencesWortmann, G., et al. 2002. Clin. Infect. Dis. 35, 261.
Pathak, M.K. and Yi, T. 2001. J. Immunol. 167, 3391.