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5677 Spermine, Tetrahydrochloride - CAS 306-67-2 - Calbiochem

Polyamine that plays an important role in the regulation of cellular proliferation and differentiation.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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5677
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
306-67-2C₁₀H₂₆N₄ . 4HCl

Products

Catalog NumberPackaging Qty/Pack
5677-5GM Plastic ampoule 5 gm
Description
OverviewPolyamine that plays an important role in the regulation of cellular proliferation and differentiation. Has both stimulatory and inhibitory effects on NMDA receptors depending on the subunit composition of the receptor. Acts as an inhibitor of phospholipase Cα and an activator of phospholipase Cδ. Inhibits DNA fragmentation and morphological apoptosis. Inhibits neuronal NOS.
Catalogue Number5677
Brand Family Calbiochem®
References
ReferencesIgarashi, K. and Williams, K. 1995. J. Pharmacol. Exp. Ther. 272, 1101.
Escargueil-Blanc, I., et al. 1994. FASEB J. 8, 1075.
Hu, J., et al. 1994. Neurosci. Lett. 175, 41.
Tompkins, T.A. and Moscarello, M.A. 1994. Biochim. Biophys. Acta 1206, 1208.
Trubiani, O., et al. 1994. Biochem. Mol. Biol. Int. 32, 1085.
Svensson, F., et al. 1993. Mol. Cell. Biochem. 124, 141.
Ask, A., et al. 1992. Cancer Lett. 66, 29.
Chida, N., et al. 1992. Brain Res. 593, 57.
Khan, A.U., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 11428.
Messena, L., et al. 1992. J. Leukoc. Biol. 52, 585.
Pawelczyk, T., et al. 1992. Arch. Biochem. Biophys. 297, 328.
Shantz, L.M., et al. 1992. Biochem. J. 288, 511.
Product Information
CAS number306-67-2
FormWhite solid
Hill FormulaC₁₀H₂₆N₄ . 4HCl
Chemical formulaC₁₀H₂₆N₄ . 4HCl
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetphospholipase C α
Secondary targetnNOS
Purity≥99% by titration
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSEJ7230000
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C under inert gas.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
5677-5GM 04055977190939

Documentation

Spermine, Tetrahydrochloride - CAS 306-67-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Spermine, Tetrahydrochloride - CAS 306-67-2 - Calbiochem Certificates of Analysis

TitleLot Number
5677

References

Reference overview
Igarashi, K. and Williams, K. 1995. J. Pharmacol. Exp. Ther. 272, 1101.
Escargueil-Blanc, I., et al. 1994. FASEB J. 8, 1075.
Hu, J., et al. 1994. Neurosci. Lett. 175, 41.
Tompkins, T.A. and Moscarello, M.A. 1994. Biochim. Biophys. Acta 1206, 1208.
Trubiani, O., et al. 1994. Biochem. Mol. Biol. Int. 32, 1085.
Svensson, F., et al. 1993. Mol. Cell. Biochem. 124, 141.
Ask, A., et al. 1992. Cancer Lett. 66, 29.
Chida, N., et al. 1992. Brain Res. 593, 57.
Khan, A.U., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 11428.
Messena, L., et al. 1992. J. Leukoc. Biol. 52, 585.
Pawelczyk, T., et al. 1992. Arch. Biochem. Biophys. 297, 328.
Shantz, L.M., et al. 1992. Biochem. J. 288, 511.

Brochure

Title
Excitotoxic Glutamate Analogs Technical Bulletin
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-October-2007 JSW
DescriptionPolyamine that plays an important role in the regulation of cellular proliferation and differentiation. Acts as an inhibitor of phopholipase C-α and an activator of phopholipase C-δ. Has both stimulatory and inhibitory effects on NMDA receptors depending on the subunit composition of the receptor. Inhibits neuronal NOS. Inhibits DNA fragmentation and morphological apoptosis.
FormWhite solid
CAS number306-67-2
RTECSEJ7230000
Chemical formulaC₁₀H₂₆N₄ . 4HCl
Structure formulaStructure formula
Purity≥99% by titration
SolubilityH₂O (20 mg/ml)
Storage +15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C under inert gas.
Toxicity Irritant
Merck USA index14, 8743
ReferencesIgarashi, K. and Williams, K. 1995. J. Pharmacol. Exp. Ther. 272, 1101.
Escargueil-Blanc, I., et al. 1994. FASEB J. 8, 1075.
Hu, J., et al. 1994. Neurosci. Lett. 175, 41.
Tompkins, T.A. and Moscarello, M.A. 1994. Biochim. Biophys. Acta 1206, 1208.
Trubiani, O., et al. 1994. Biochem. Mol. Biol. Int. 32, 1085.
Svensson, F., et al. 1993. Mol. Cell. Biochem. 124, 141.
Ask, A., et al. 1992. Cancer Lett. 66, 29.
Chida, N., et al. 1992. Brain Res. 593, 57.
Khan, A.U., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 11428.
Messena, L., et al. 1992. J. Leukoc. Biol. 52, 585.
Pawelczyk, T., et al. 1992. Arch. Biochem. Biophys. 297, 328.
Shantz, L.M., et al. 1992. Biochem. J. 288, 511.