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567735 Sphingosylphosphoryl-choline - CAS 1670-26-4 - Calbiochem

SPC is the deacylated derivative of sphingomyelin known to accumulate in neuropathic Niemann-Pick disease type A.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: SPC, lyso-Sphingomyelin

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567735
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
1670-26-4C₂₃H₄₉N₂O₅P

Products

Catalog NumberPackaging Qty/Pack
567735-10MG Plastic ampoule 10 mg
Description
OverviewSPC is the deacylated derivative of sphingomyelin known to accumulate in neuropathic Niemann-Pick disease type A. A potent mitogen that increases intracellular free Ca2+ and free arachidonate through pathways that are only partially PKC-dependent. Stimulates DNA-binding activity of the transcription activator protein AP-1. Rapidly induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and paxillin and causes a rapid and transient activation of MAP kinase in Swiss/3T3 cells. Also induces a unique reorganization of the actin cytoskeleton.
Catalogue Number567735
Brand Family Calbiochem®
SynonymsSPC, lyso-Sphingomyelin
References
ReferencesBerger, A., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 5885.
Dettbarn, C., et al. 1995. Brain Res. 669, 79.
Seufferlein, T. and Rozengurt, E. 1995. J. Biol. Chem. 270, 24343.
Seufferlein, T. and Rozengurt, E. 1995. J. Biol. Chem. 270, 24334.
Product Information
CAS number1670-26-4
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₃H₄₉N₂O₅P
Chemical formulaC₂₃H₄₉N₂O₅P
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetA potent mitogen
Purity≥98% by TLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
567735-10MG 04055977190908

Documentation

Sphingosylphosphoryl-choline - CAS 1670-26-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Sphingosylphosphoryl-choline - CAS 1670-26-4 - Calbiochem Certificates of Analysis

TitleLot Number
567735

References

Reference overview
Berger, A., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 5885.
Dettbarn, C., et al. 1995. Brain Res. 669, 79.
Seufferlein, T. and Rozengurt, E. 1995. J. Biol. Chem. 270, 24343.
Seufferlein, T. and Rozengurt, E. 1995. J. Biol. Chem. 270, 24334.

Brochure

Title
Bioactive Lipids Technical Bulletin
MAPK Pathway Poster ( 750 KB )
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-September-2008 RFH
SynonymsSPC, lyso-Sphingomyelin
DescriptionSPC is the deacylated derivative of sphingomyelin known to accumulate in neuropathic Niemann-Pick disease type A. A potent mitogen that increases intracellular free Ca2+ and free arachidonate through pathways that are only partially PKC-dependent. Stimulates DNA-binding activity of the transcription activator protein AP-1. Rapidly induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and paxillin and causes a rapid and transient activation of MAP kinase in Swiss 3T3 cells. Also induces a unique reorganization of the actin cytoskeleton.
FormWhite solid
CAS number1670-26-4
Chemical formulaC₂₃H₄₉N₂O₅P
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityChloroform:Methanol (2:1) (1 mg/ml)
Storage Protect from moisture
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Toxicity Standard Handling
ReferencesBerger, A., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 5885.
Dettbarn, C., et al. 1995. Brain Res. 669, 79.
Seufferlein, T. and Rozengurt, E. 1995. J. Biol. Chem. 270, 24343.
Seufferlein, T. and Rozengurt, E. 1995. J. Biol. Chem. 270, 24334.