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567809 Src Inhibitor, PP1 - CAS 172889-26-8 - Calbiochem

The Src Inhibitor PP1, also referenced under CAS 172889-26-8, controls the biological activity of Src. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-amino-5-(4-methylphenyl)-7-(t-butyl)pyrazolo-d-3,4-pyrimidine

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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
172889-26-8C₁₆H₁₉N₅

Products

Catalog NumberPackaging Qty/Pack
567809-1MG Glass bottle 1 mg
Description
OverviewA cell-permeable pyrazolopyrimidine compound that is shown to inhibit Src family tyrosine kinases Lck, Fyn, Hck, and Src (IC50 = 5, 6, 20, and 170 nM, respectively), as well as non-Src family kinases such as CSK, RIP2, and CK1δ (IC50 = 640 nM, 26 nM, 170 nM, respectively), in in vitro kinase assays. At 1 µM, in vitro kinase activity is reduced by more than 57% for p38α, p38β, CK1δ, CSK, RIP2, and GAK, while exhibiting much lower activity against more than 60 other kinases. Kinetic studies employing Src and [poly Glu-Tyr 4:1] indicate that the inhibition is mixed competitive with respect to the substrate and non-competitive with respect to ATP. PP1 also demonstrates anti-growth properties in several B lymphoma cultures of human and murine origins (IC50 = 2.5 to 8.0 µM) and pediatric brain tumor cells (IC50 = 1.1 to 9.7 µM). Also available in InSolution™ format (Cat. No. 539741).
Catalogue Number567809
Brand Family Calbiochem®
Synonyms4-amino-5-(4-methylphenyl)-7-(t-butyl)pyrazolo-d-3,4-pyrimidine
References
ReferencesKe, J., et.al. 2009. Mol. Cancer 8, 132.
Sikkema, A.H., et al. 2009. Cancer Res. 69, 5987.
Bain, J., et al. 2007. Biochem. J. 408, 297.
Bain, J., et al. 2003. Biochem. J. 371, 199.
Karni, R., et al. 2003. FEBS Lett. 537, 47.
Hanke, J.H., et al. 1996. J. Biol. Chem. 271, 695.
Product Information
CAS number172889-26-8
FormOff-white solid
Hill FormulaC₁₆H₁₉N₅
Chemical formulaC₁₆H₁₉N₅
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
567809-1MG 04055977190373

Documentation

Src Inhibitor, PP1 - CAS 172889-26-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Src Inhibitor, PP1 - CAS 172889-26-8 - Calbiochem Certificates of Analysis

TitleLot Number
567809

References

Reference overview
Ke, J., et.al. 2009. Mol. Cancer 8, 132.
Sikkema, A.H., et al. 2009. Cancer Res. 69, 5987.
Bain, J., et al. 2007. Biochem. J. 408, 297.
Bain, J., et al. 2003. Biochem. J. 371, 199.
Karni, R., et al. 2003. FEBS Lett. 537, 47.
Hanke, J.H., et al. 1996. J. Biol. Chem. 271, 695.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-April-2015 JSW
Synonyms4-amino-5-(4-methylphenyl)-7-(t-butyl)pyrazolo-d-3,4-pyrimidine
DescriptionA cell-permeable pyrazolopyrimidine compound that is shown to inhibit Src family tyrosine kinases Lck, Fyn, Hck, and Src (IC50 = 5, 6, 20, and 170 nM, respectively), as well as non-Src family kinases such as CSK, RIP2, and CK1δ (IC50 = 640 nM, 26 nM, 170 nM, respectively), in in vitro kinase assays. At 1 µM, in vitro kinase activity is reduced by more than 57% for p38α, p38β, CK1δ, CSK, RIP2, and GAK, while exhibiting much lower activity against more than 60 other kinases. Kinetic studies employing Src and [poly Glu-Tyr 4:1] indicate that the inhibition is mixed competitive with respect to the substrate and non-competitive with respect to ATP. PP1 also demonstrates anti-growth properties in several B lymphoma cultures of human and murine origins (IC50 = 2.5 to 8.0 µM) and pediatric brain tumor cells (IC50 = 1.1 to 9.7 µM). Also available in InSolution™ format (Cat. No. 539741.
FormOff-white solid
CAS number172889-26-8
Chemical formulaC₁₆H₁₉N₅
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (25 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesKe, J., et.al. 2009. Mol. Cancer 8, 132.
Sikkema, A.H., et al. 2009. Cancer Res. 69, 5987.
Bain, J., et al. 2007. Biochem. J. 408, 297.
Bain, J., et al. 2003. Biochem. J. 371, 199.
Karni, R., et al. 2003. FEBS Lett. 537, 47.
Hanke, J.H., et al. 1996. J. Biol. Chem. 271, 695.