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574714 Syk Inhibitor IV, BAY 61-3606 - CAS 732983-37-8 - Calbiochem

Syk Inhibitor IV, BAY 61-3606, CAS 732938-37-8, is a cell-permeable, potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (IC50 = 10 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(7-(3,4-Dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino)-nicotinamide, HCl, BAY 61-3606

Primary Target: Syk
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
732983-37-8C₂₀H₁₈N₆O₃ • HCl • H₂O

Products

Catalog NumberPackaging Qty/Pack
574714-2MG Glass bottle 2 mg
Description
OverviewA cell-permeable imidazopyrimidine compound that acts a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (IC50 = 10 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src even at concentrations as high as 4.7 µM. Shown to inhibit Syk-mediated cellular functions in vitro and exhibit good oral bioavailability and in vivo effacacy in the treatment of various allgery and asthma conditions in rat models.
Catalogue Number574714
Brand Family Calbiochem®
Synonyms2-(7-(3,4-Dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino)-nicotinamide, HCl, BAY 61-3606
References
ReferencesYamamoto, N., et al. 2003. J. Pharm. Exp. Ther. 306, 1174.
Product Information
CAS number732983-37-8
ATP CompetitiveY
FormYellow solid
Hill FormulaC₂₀H₁₈N₆O₃ • HCl • H₂O
Chemical formulaC₂₀H₁₈N₆O₃ • HCl • H₂O
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationSyk Inhibitor IV, BAY 61-3606, CAS 732938-37-8, is a cell-permeable, potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (IC50 = 10 nM).
Biological Information
Primary TargetSyk
Primary Target IC<sub>50</sub>10 nM
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
574714-2MG 04055977189698

Documentation

Syk Inhibitor IV, BAY 61-3606 - CAS 732983-37-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Syk Inhibitor IV, BAY 61-3606 - CAS 732983-37-8 - Calbiochem Certificates of Analysis

TitleLot Number
574714

References

Reference overview
Yamamoto, N., et al. 2003. J. Pharm. Exp. Ther. 306, 1174.

Brochure

Title
Biologics 33.2
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-September-2020 JSW
Synonyms2-(7-(3,4-Dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino)-nicotinamide, HCl, BAY 61-3606
DescriptionA cell-permeable imidazopyrimidine compound that acts a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (IC50 = 10 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src even at concentrations as high as 4.7 µM. Shown to inhibit Syk-mediated cellular functions in vitro and exhibit good oral bioavailability and in vivo effacacy in the treatment of various allgery and asthma conditions in rat models.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number732983-37-8
Chemical formulaC₂₀H₁₈N₆O₃ • HCl • H₂O
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (10 mg/ml) or H₂O (20 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesYamamoto, N., et al. 2003. J. Pharm. Exp. Ther. 306, 1174.