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538184 Synoviolin Inhibitor, LS-102 - Calbiochem

Synoviolin Inhibitor, LS-102 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (S)-N²-(benzo[d]oxazol-6-yl)-N⁴-(1-cyclohexylethyl)-N⁶-ethyl-N⁶-(2-(ethylamino)ethyl)-1,3,5-triazine-2,4,6-triamine, E3 Ligase SYVN Inhibitor, LS-102, LS102

Primary Target: Synoviolin
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₄H₃₆N₈O

Products

Catalog NumberPackaging Qty/Pack
5.38184.0001 Glass bottle 10 mg
Description
OverviewA cell-permeable triaminotriazine that selectively inhibits the autoubiquitnation of the E3 ubiquitin ligase synoviolin (SYVN1, IC50 = 35 µM), without affecting other E3 ubiquitin ligases. Abolished the SYVN-mediated negative regulation of PGC-1β via reduced ubiquitination. Shown to induce the expression of PGC-1β in wild type mouse embryonic fibroblasts (MEF), but does not affect PGC-1β expression in SYVN knockout MEFs. Increases mitochondrial biogenesis in C57BL/6J mice. Also increases the energy expenditure and causes a significant reduction in body weight and blood glucose levels in db/db mice (50 mg/kg, i.p daily) without influencing their food intake. Suppresses the proliferation of rheumatoid synovial cells (IC50 = 5.4 µM) and reduces the severity of rheumatoid arthritis in a mouse model (4 mg/kg).

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number538184
Brand Family Calbiochem®
Synonyms(S)-N²-(benzo[d]oxazol-6-yl)-N⁴-(1-cyclohexylethyl)-N⁶-ethyl-N⁶-(2-(ethylamino)ethyl)-1,3,5-triazine-2,4,6-triamine, E3 Ligase SYVN Inhibitor, LS-102, LS102
References
ReferencesYagishita, N., et al. 2012. Int. J. Mol. Med. 30, 1281.
Fujita, F., et al. 2015. EMBO J. 34, 12192.
Product Information
FormPurple solid
Hill FormulaC₂₄H₃₆N₈O
Chemical formulaC₂₄H₃₆N₈O
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetSynoviolin
Primary Target IC<sub>50</sub>35 µ
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
5.38184.0001 04054839116278

Documentation

Synoviolin Inhibitor, LS-102 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Yagishita, N., et al. 2012. Int. J. Mol. Med. 30, 1281.
Fujita, F., et al. 2015. EMBO J. 34, 12192.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-March-2017 JSW
Synonyms(S)-N²-(benzo[d]oxazol-6-yl)-N⁴-(1-cyclohexylethyl)-N⁶-ethyl-N⁶-(2-(ethylamino)ethyl)-1,3,5-triazine-2,4,6-triamine, E3 Ligase SYVN Inhibitor, LS-102, LS102
DescriptionA cell-permeable triaminotriazine that selectively inhibits the autoubiquitnation of the E3 ubiquitin ligase synoviolin (SYVN1, IC50 = 35 µM), without affecting other E3 ubiquitin ligases. Abolished the SYVN-mediated negative regulation of PGC-1β via reduced ubiquitination. Shown to induce the expression of PGC-1β in wild type mouse embryonic fibroblasts (MEF), but does not affect PGC-1β expression in SYVN knockout MEFs. Increases mitochondrial biogenesis in C57BL/6J mice. Also increases the energy expenditure and causes a significant reduction in body weight and blood glucose levels in db/db mice (50 mg/kg, i.p daily) without influencing their food intake. Suppresses the proliferation of rheumatoid synovial cells (IC50 = 5.4 µM) and reduces the severity of rheumatoid arthritis in a mouse model (4 mg/kg).
FormPurple solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₄H₃₆N₈O
Purity≥97% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesYagishita, N., et al. 2012. Int. J. Mol. Med. 30, 1281.
Fujita, F., et al. 2015. EMBO J. 34, 12192.