579052 Sigma-AldrichTAPI-2 - CAS 187034-31-7 - Calbiochem
TAPI-2, CAS 187034-31-7, is a hydroxamate-based inhibitor of MMPs and TACE. Inhibits the activation-induced shedding of L-selectin from neutrophils, eosinophils, and lymphocytes.
More>> TAPI-2, CAS 187034-31-7, is a hydroxamate-based inhibitor of MMPs and TACE. Inhibits the activation-induced shedding of L-selectin from neutrophils, eosinophils, and lymphocytes. Less<<TAPI-2 - CAS 187034-31-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-t-butyl-alanyl-L-alanine, 2-aminoethyl Amide, TNF-α Protease Inhibitor-2
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Overview
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Key Specifications Table
| CAS # | Empirical Formula |
|---|---|
| 187034-31-7 | C₁₉H₃₇N₅O₅ |
Products
| Catalog Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 579052-1MG | Plastic ampoule | 1 mg |
| Description | |
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| Overview | A hydroxamate-based inhibitor of MMPs and TACE. Inhibits the activation-induced shedding of L-selectin from neutrophils, eosinophils, and lymphocytes, as well as phenylarsine oxide (PAO)-induced shedding in neutrophils. Also acts as a weak inhibitor of angiotensin converting enzyme (IC50 = 18 µM). Also available as a 10 mM solution in H2O (Cat. No. 509612). |
| Catalogue Number | 579052 |
| Brand Family | Calbiochem® |
| Synonyms | N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-t-butyl-alanyl-L-alanine, 2-aminoethyl Amide, TNF-α Protease Inhibitor-2 |
| Product Information | |
|---|---|
| CAS number | 187034-31-7 |
| ATP Competitive | N |
| Declaration | Manufactured exclusively by Peptides International, Louisville, Kentucky, USA. |
| Form | White solid |
| Hill Formula | C₁₉H₃₇N₅O₅ |
| Chemical formula | C₁₉H₃₇N₅O₅ |
| Hygroscopic | Hygroscopic |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | MMPs |
| Primary Target IC<sub>50</sub> | 18 µM against angiotensin converting enzyme |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
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| Cell permeable | N |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 579052-1MG | 04055977265378 |
Documentation
TAPI-2 - CAS 187034-31-7 - Calbiochem SDS
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TAPI-2 - CAS 187034-31-7 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 579052 |
References
| Reference overview |
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| Bennett, T.A., et al. 2000. J. Immunol. 164, 4120. Fiorucci, S., et al. 1998. Aliment. Pharmacol. Ther. 12, 1139. Hooper, N.M., et al. 1997. Biochem. J. 321, 265. Parvathy, S., et al. 1997. Biochem. J. 327, 37. Arribas, J., et al. 1996. J. Biol. Chem. 271, 11376. |