616452 MilliporeTGF-β RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem
TGF-β RI Kinase Inhibitor II, CAS 446859-33-2, is a cell-permeable, potent, reversible, ATP-competitive inhibitor of TGF-β R1 kinase (IC₅₀ = 23 nM and 4 nM for ALK5 binding & auto-phosphorylation).
More>> TGF-β RI Kinase Inhibitor II, CAS 446859-33-2, is a cell-permeable, potent, reversible, ATP-competitive inhibitor of TGF-β R1 kinase (IC₅₀ = 23 nM and 4 nM for ALK5 binding & auto-phosphorylation). Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: ALK5 Inhibitor II, Transforming Growth Factor-β Type I Receptor Kinase Inhibitor II, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
Recommended Products
Overview
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Key Specifications Table
| CAS # | Empirical Formula |
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| 446859-33-2 | C₁₇H₁₃N₅ |
Products
| Catalog Number | Packaging | Qty/Pack | |
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| 616452-2MG | Glass bottle | 2 mg |
| Description | |
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| Overview | A cell-permeable naphthyridinyl pyrazolo compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of TGF-β type I receptor (ALK5; IC50 = 23 nM, 4 nM and 18 nM for ALK5 binding, ALK5 auto-phosphorylation and TGF-β cellular assay in HepG2 cells, respectively). Minimally affects a panel of 9 closely related kinases including p38 MAPK at IC50 > 16 µM. Also available as a 50 mM solution in DMSO (Cat. No. 508158). |
| Catalogue Number | 616452 |
| Brand Family | Calbiochem® |
| Synonyms | ALK5 Inhibitor II, Transforming Growth Factor-β Type I Receptor Kinase Inhibitor II, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine |
| References | |
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| References | Gellibert, F., et al. 2004. J. Med. Chem. 47, 4494. Ichida, J. K., et al. 2009. 5, 491. |
| Product Information | |
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| CAS number | 446859-33-2 |
| ATP Competitive | Y |
| Form | Yellow solid |
| Hill Formula | C₁₇H₁₃N₅ |
| Chemical formula | C₁₇H₁₃N₅ |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | ALKS binding |
| Primary Target IC<sub>50</sub> | 23 nM |
| Secondary target | ALK 5 auto phosphorylation (IC₅₀ = 4 nM) |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 616452-2MG | 04055977185829 |
Documentation
TGF-β RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem SDS
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TGF-β RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 616452 |
References
| Reference overview |
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| Gellibert, F., et al. 2004. J. Med. Chem. 47, 4494. Ichida, J. K., et al. 2009. 5, 491. |
Brochure
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| TGF-b Signaling: Dual Role in Tumor Suppression and Oncogenesis |
Technical Info
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| TGF-β Signaling: Dual Role in Tumor Suppression and Oncogenesis |
Citations
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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