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616453 TGF-β RI Kinase Inhibitor III - CAS 356559-13-2 - Calbiochem

The TGF-β RI Kinase Inhibitor III, also referenced under CAS 356559-13-2, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Transforming Growth Factor-β Type I Receptor Kinase Inhibitor III, 2-(5-Benzo[1,3]dioxol-4-yl-2-tert-butyl-1H-imidazol-4-yl)-6-methylpyridine, HCl, ALK5 Inhibitor III, SB-505124, HCl

Primary Target: Activin receptor-like kinase 4, 5, 7
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
356559-13-2C₂₀H₂₁N₃O₂ • HCl

Products

Catalog NumberPackaging Qty/Pack
616453-2MG Plastic ampoule 2 mg
Description
OverviewA cell-permeable imidazolyl-pyridine compound that acts as a potent, ATP-competitive, reversible, and selective inhibitor of activin receptor-like kinase 4 (IC50 = 129 nM), 5 ( IC50 = 47 nM), and 7. It inhibits p38 MAPKα only at much higher concentrations (IC50 = 10.6 µM) and has little effect against ALK1/2/3/6 as well as a panel of 26 other kinases.
Catalogue Number616453
Brand Family Calbiochem®
SynonymsTransforming Growth Factor-β Type I Receptor Kinase Inhibitor III, 2-(5-Benzo[1,3]dioxol-4-yl-2-tert-butyl-1H-imidazol-4-yl)-6-methylpyridine, HCl, ALK5 Inhibitor III, SB-505124, HCl
References
ReferencesHu, T., et al. 2005. Am. J. Physiol. Renal Physiol. 289, F816.
DaCosta Byfield, S., et al. 2004. Mol. Pharmacol. 65, 744.
Product Information
CAS number356559-13-2
ATP CompetitiveY
FormLight yellow solid
Hill FormulaC₂₀H₂₁N₃O₂ • HCl
Chemical formulaC₂₀H₂₁N₃O₂ • HCl
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetActivin receptor-like kinase 4, 5, 7
Primary Target IC<sub>50</sub>129 nM, 47 nM, against activin receptor-like kinase 4, 5, respectively
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
616453-2MG 04055977185843

Documentation

TGF-β RI Kinase Inhibitor III - CAS 356559-13-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

TGF-β RI Kinase Inhibitor III - CAS 356559-13-2 - Calbiochem Certificates of Analysis

TitleLot Number
616453

References

Reference overview
Hu, T., et al. 2005. Am. J. Physiol. Renal Physiol. 289, F816.
DaCosta Byfield, S., et al. 2004. Mol. Pharmacol. 65, 744.

Brochure

Title
TGF-b Signaling: Dual Role in Tumor Suppression and Oncogenesis

Technical Info

Title
TGF-β Signaling: Dual Role in Tumor Suppression and Oncogenesis
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-September-2008 RFH
SynonymsTransforming Growth Factor-β Type I Receptor Kinase Inhibitor III, 2-(5-Benzo[1,3]dioxol-4-yl-2-tert-butyl-1H-imidazol-4-yl)-6-methylpyridine, HCl, ALK5 Inhibitor III, SB-505124, HCl
DescriptionA cell-permeable imidazolyl-pyridine compound that acts as a potent, ATP-competitive, reversible, and selective inhibitor of activin receptor-like kinase 4 (IC50 = 129 nM), 5 ( IC50 = 47 nM), and 7. It inhibits p38 MAPKα only at much higher concentrations (IC50 = 10.6 µM) and has little effect against ALK1/2/3/6 as well as a panel of 26 other kinases.
FormLight yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number356559-13-2
Chemical formulaC₂₀H₂₁N₃O₂ • HCl
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (20 mg/ml) or H₂O (3 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesHu, T., et al. 2005. Am. J. Physiol. Renal Physiol. 289, F816.
DaCosta Byfield, S., et al. 2004. Mol. Pharmacol. 65, 744.