613450 Sigma-AldrichTOFA - CAS 54857-86-2 - Calbiochem
A cell-permeable furoic acid compound that acts as a potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in the fatty acid biosynthesis.
More>> A cell-permeable furoic acid compound that acts as a potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in the fatty acid biosynthesis. Less<<TOFA - CAS 54857-86-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 5-(Tetradecyloxy)-2-furoic acid
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Overview
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Key Specifications Table
| CAS # | Empirical Formula |
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| 54857-86-2 | C₁₉H₃₂O₄ |
Products
| Catalog Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 613450-5MG | Plastic ampoule | 5 mg |
| Description | |
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| Overview | A cell-permeable furoic acid compound that acts as a potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in the fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner (IC50 = 4 µM in human breast cancer cell line MCF7). TOFA-induced reduction in malonyl-CoA is reported to off-set the effect of C75 (Cat. No. 341325) on food intake in fasted mice and on apoptosis in tumor cells. |
| Catalogue Number | 613450 |
| Brand Family | Calbiochem® |
| Synonyms | 5-(Tetradecyloxy)-2-furoic acid |
| Product Information | |
|---|---|
| CAS number | 54857-86-2 |
| ATP Competitive | Y |
| Form | Off-white solid |
| Hill Formula | C₁₉H₃₂O₄ |
| Chemical formula | C₁₉H₃₂O₄ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | Acetyl-CoA carboxylase (ACC) |
| Primary Target IC<sub>50</sub> | 4 µM inhibiting cellular fatty acid synthesis in human breast cancer cell line MCF7 |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Safety Information |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 613450-5MG | 04055977263787 |
Documentation
TOFA - CAS 54857-86-2 - Calbiochem SDS
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TOFA - CAS 54857-86-2 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 613450 |
References
| Reference overview |
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| Landree, L.E., et al. 2004. J. Biol. Chem. 279, 3817. Zhou, W., et al. 2003. Cancer Res. 63, 7330. Hu, Z., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 12624. Pizer, E.S., et al. 2000. Cancer Res. 60, 213. Arbeeny, C.M., et al. 1992. J. Lipid Res. 33, 843. Fukuda, N. and Ontko, J.A. 1984. J. Lipid Res. 25, 831. |