648494 Sigma-AldrichTPRC3 Channel Inhibitor III, Pyr10 - CAS 1315323-00-2 - Calbiochem
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Overview
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Products
| Catalog Number | Packaging | Qty/Pack | |
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| 648494-10MG | Glass bottle | 10 mg |
| Description | |
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| Overview | A cell-permeable pyrazole derivative that acts as a selective blocker of the transient receptor potential cation channel TRPC3-medated ROCE (receptor-operated Ca2+ entry) and inhibits Carbachol- (Cat. No. 212385) induced Ca2+ entry in TRPC3-expressing HEK293 cells (IC50 = 0.72 µM; by Fura-2), while exhibiting much reduced potency against Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 13.08 µM; by Fura-2). A great complement to Pyr2 (Cat. No. 203890), Pyr 3 (Cat. No. 648490), and Pyr6 (Cat. No. 203891) in Ca2+ signaling studies. |
| Catalogue Number | 648494 |
| Brand Family | Calbiochem® |
| Synonyms | N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-4-methylbenzenesulfonamide |
| References | |
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| References | Schleifer, H. et al. 2012. Br. J. Pharmacol. 167, 1712. |
| Product Information | |
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| CAS number | 1315323-00-2 |
| Form | White to off-white solid |
| Hill Formula | C₁₈H₁₃F₆N₃O₂S |
| Chemical formula | C₁₈H₁₃F₆N₃O₂S |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Primary Target | TRPC3 |
| Primary Target IC<sub>50</sub> | 720 nM |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 648494-10MG | 04055977185096 |
Documentation
TPRC3 Channel Inhibitor III, Pyr10 - CAS 1315323-00-2 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 648494 |
References
| Reference overview |
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| Schleifer, H. et al. 2012. Br. J. Pharmacol. 167, 1712. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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