648490 Sigma-AldrichTRPC3 Channel Inhibitor, Pyr3 - CAS 1160514-60-2 - Calbiochem
The TRPC3 Channel Inhibitor, Pyr3, also referenced under CAS 1160514-60-2, controls the biological activity of TRPC3 Channel. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
More>> The TRPC3 Channel Inhibitor, Pyr3, also referenced under CAS 1160514-60-2, controls the biological activity of TRPC3 Channel. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Ethyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate, SB-360475, CRAC Channel Inhibitor II
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Overview
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Key Specifications Table
| CAS # | Empirical Formula |
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| 1160514-60-2 | C₁₆H₁₁Cl₃F₃N₃O₃ |
Products
| Catalog Number | Packaging | Qty/Pack | |
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| 648490-10MG | Plastic ampoule | 10 mg |
| Description | |
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| Overview | A cell-permeable pyrazole that acts as an equally potent blocker of Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 540 nM by Fura-2; peak current density pA/pF = -1.45 and -7.50, respectively, with or without 3 µM BTP2/Pyr3 by whole cell clamp) and the transient receptor potential cation channel TRPC3-mediated ROCE (receptor-operated Ca2+ entry) in TRPC3-expressing HEK293 cells (IC50 = 540 nM; by Fura-2; pA/pF = -2.27 and -18.50, respectively, with or without 3 µM BTP2/Pyr3). Pyr3 is also demonstrated to alleviate pressure overload-induced cardiac hypertrophy following TAC (transverse aortic constriction) operation in mice (0.1 mg/kg/day via i.p. osmotic pump) in vivo. A great complement to Pyr 2 (Cat. No. 203890), Pyr6, and Pyr10 in Ca2+ signaling studies. |
| Catalogue Number | 648490 |
| Brand Family | Calbiochem® |
| Synonyms | Ethyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate, SB-360475, CRAC Channel Inhibitor II |
| References | |
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| References | Schleifier, H., et al. 2012. Br J Pharmacol In Press Kiyonaka, S., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 5400. |
| Product Information | |
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| CAS number | 1160514-60-2 |
| Form | White to beige solid |
| Hill Formula | C₁₆H₁₁Cl₃F₃N₃O₃ |
| Chemical formula | C₁₆H₁₁Cl₃F₃N₃O₃ |
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| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥95% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 648490-10MG | 04055977185065 |
Documentation
TRPC3 Channel Inhibitor, Pyr3 - CAS 1160514-60-2 - Calbiochem SDS
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TRPC3 Channel Inhibitor, Pyr3 - CAS 1160514-60-2 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 648490 |
References
| Reference overview |
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| Schleifier, H., et al. 2012. Br J Pharmacol In Press Kiyonaka, S., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 5400. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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