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554412 Tetrodotoxin, Citrate, Fugu sp. - CAS 4368-28-9 - Calbiochem

Tetrodotoxin, Fugu sp., CAS 18660-81-6, is a reversible blocker of Na+ channels. Inhibits the release of glutamate via Na+-dependent glutamate transporter.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: TTx

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554412
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Overview

Replacement Information

Products

Catalog NumberPackaging Qty/Pack
554412-1MG Alu drum 1 mg
Description
OverviewReversibly blocks Na+ channels, which are essential for the propagation of impulses in excitable membranes. Useful as a marker of Na+ channels in excitable tissues. Inhibits the release of glutamate via Na+-dependent glutamate transporter and prevents veratradine-induced intracellular Ca2+ accumulation (IC50 = 63 nM).
Catalogue Number554412
Brand Family Calbiochem®
SynonymsTTx
References
ReferencesLysko, P.G., et al. 1994. Stroke 25, 2476.
Hu, S.L. and Kao, C.Y. 1985. Toxicon 23, 723.
Nakamura, M. and Yasumoto, T. 1985. Toxicon 23, 271.
Product Information
CAS number4368-28-9
ATP CompetitiveN
DeclarationNot available for sale outside of the United States.
FormWhite solid
FormulationCrystalline solid. Contains sodium citrate.
Hill FormulaC₁₁H₁₇N₃O₈
Chemical formulaC₁₁H₁₇N₃O₈
ReversibleY
Quality LevelMQ100
Applications
ApplicationTetrodotoxin, Fugu sp., CAS 18660-81-6, is a reversible blocker of Na+ channels. Inhibits the release of glutamate via Na+-dependent glutamate transporter.
Biological Information
Primary TargetNa+ channels
Primary Target IC<sub>50</sub>63 nM Iinhibiting the release of glutamate via Na+-dependent glutamate transporter and prevents veratradine-induced intracellular Ca2+ accumulation
Purity≥98%
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSIO1450000
Safety Information
R PhraseR: 28

Very toxic if swallowed.
S PhraseS: 22-36/37/39-45

Do not breathe dust.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Highly Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Activity is destroyed if exposed to alkaline or strongly acidic conditions.
End use certificateY
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
554412-1MG 04055977193077

Documentation

Tetrodotoxin, Citrate, Fugu sp. - CAS 4368-28-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Tetrodotoxin, Citrate, Fugu sp. - CAS 4368-28-9 - Calbiochem Certificates of Analysis

TitleLot Number
554412

References

Reference overview
Lysko, P.G., et al. 1994. Stroke 25, 2476.
Hu, S.L. and Kao, C.Y. 1985. Toxicon 23, 723.
Nakamura, M. and Yasumoto, T. 1985. Toxicon 23, 271.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-August-2008 JSW
SynonymsTTx
DescriptionReversibly blocks Na+ channels, which are essential for the propagation of impulses in excitable membranes. Useful as a marker of Na+ channels in excitable tissues. Inhibits the release of glutamate via Na+-dependent glutamate transporter and prevents veratradine-induced intracellular Ca2+ accumulation (IC50 = 63 nM).
FormWhite solid
FormulationCrystalline solid. Contains sodium citrate.
CAS number4368-28-9
RTECSIO1450000
Chemical formulaC₁₁H₁₇N₃O₈
Purity≥98%
SolubilityH₂O (1 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Activity is destroyed if exposed to alkaline or strongly acidic conditions.
Toxicity Highly Toxic
Merck USA index14, 9246
ReferencesLysko, P.G., et al. 1994. Stroke 25, 2476.
Hu, S.L. and Kao, C.Y. 1985. Toxicon 23, 723.
Nakamura, M. and Yasumoto, T. 1985. Toxicon 23, 271.