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586005 Thapsigargin - CAS 67526-95-8 - Calbiochem

Thapsigargin, CAS 67526-95-8, is a cell-permeable, tumor-promoting sesquiterpene lactone that releases calcium by non-competitvley inhibiting endoplasmic reticular Ca2+-ATPase (IC₅₀ = 4-13 nM).

Thapsigargin - CAS 67526-95-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: endoplasmic reticular Ca2+ ATPase
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586005
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
67526-95-8C₃₄H₅₀O₁₂

Products

Catalog NumberPackaging Qty/Pack
586005-1MG Plastic ampoule 1 mg
Description
OverviewA cell-permeable tumor-promoting sesquiterpene lactone that releases Ca2+ by inhibiting endoplasmic reticular Ca2+-ATPase (IC50 = 4-13 nM). Does not increase inositol phosphates and has no significant effect on protein kinase C. Increases Ca2+-dependent Na+ influx in human platelets in a dose-dependent manner. Induces apoptosis in rat thymocytes and in human hepatoma cells. Shown to induce apoptosis in alveolar rhabdomyosarcoma cells by elevating Akt-stimulated PAX3-FOXO1 phosphorylation and promoting its proteasomal degradation.
Catalogue Number586005
Brand Family Calbiochem®
References
ReferencesJothi, M., et al. 2013. Mol. Cancer Ther. In press.
Won, J.G. and Orth, D.N. 1995. Endocrinology 136, 5399.
Tepel, M., et al. 1994. Biochim. Biophys. Acta 1220, 248.
Begum, N., et al. 1993. J. Biol. Chem. 268, 3352.
Low, A.M., et al. 1993. Eur. J. Pharmacol. 230, 53.
Tsukamoto, A. and Karneko, Y. 1993. Cell. Biol. Int. 17, 969.
Wong, W.L., et al. 1993. Biochem. J. 289, 71.
Glennon, M.C., et al. 1992. J. Biol. Chem. 267, 25568.
Xu, Y., et al. 1992. J. Neurochem. 59, 2224.
Mason, M.J., et al. 1991. J. Biol. Chem. 266, 20856.
Thastrup, O., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 2466.
Product Information
CAS number67526-95-8
ATP CompetitiveN
FormColorless solid
Hill FormulaC₃₄H₅₀O₁₂
Chemical formulaC₃₄H₅₀O₁₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
Biological Information
Primary Targetendoplasmic reticular Ca2+ ATPase
Primary Target IC<sub>50</sub>4-13 nM against endoplasmic reticular Ca2+-ATPase
Purity≥97% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38-42

Irritating to eyes, respiratory system and skin.
May cause sensitization by inhalation.
S PhraseS: 36/37/39-26

Wear suitable protective clothing, gloves and eye/face protection.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 2-3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
586005-1MG 04055977265026

Documentation

Thapsigargin - CAS 67526-95-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Thapsigargin - CAS 67526-95-8 - Calbiochem Certificates of Analysis

TitleLot Number
586005

References

Reference overview
Jothi, M., et al. 2013. Mol. Cancer Ther. In press.
Won, J.G. and Orth, D.N. 1995. Endocrinology 136, 5399.
Tepel, M., et al. 1994. Biochim. Biophys. Acta 1220, 248.
Begum, N., et al. 1993. J. Biol. Chem. 268, 3352.
Low, A.M., et al. 1993. Eur. J. Pharmacol. 230, 53.
Tsukamoto, A. and Karneko, Y. 1993. Cell. Biol. Int. 17, 969.
Wong, W.L., et al. 1993. Biochem. J. 289, 71.
Glennon, M.C., et al. 1992. J. Biol. Chem. 267, 25568.
Xu, Y., et al. 1992. J. Neurochem. 59, 2224.
Mason, M.J., et al. 1991. J. Biol. Chem. 266, 20856.
Thastrup, O., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 2466.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-October-2013 JSW
DescriptionA cell-permeable tumor-promoting sesquiterpene lactone that releases Ca2+ by inhibiting endoplasmic reticular Ca2+-ATPase. Does not increase inositol phosphates and has no significant effect on protein kinase C. Increases Ca2+-dependent Na+ influx in human platelets in a dose-dependent manner. Activates apoptosis in rat thymocytes and induces apoptosis in human hepatoma cells. Shown to induce apoptosis in alveolar rhabdomyosarcoma cells by elevating Akt-stimulated PAX3-FOXO1 phosphorylation and promoting its proteasomal degradation.
FormColorless solid
CAS number67526-95-8
Chemical formulaC₃₄H₅₀O₁₂
Structure formulaStructure formula
Purity≥97% by TLC
SolubilityDMSO (>1 mg/ml) or ethanol (5 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 2-3 months at -20°C.
Toxicity Irritant
ReferencesJothi, M., et al. 2013. Mol. Cancer Ther. In press.
Won, J.G. and Orth, D.N. 1995. Endocrinology 136, 5399.
Tepel, M., et al. 1994. Biochim. Biophys. Acta 1220, 248.
Begum, N., et al. 1993. J. Biol. Chem. 268, 3352.
Low, A.M., et al. 1993. Eur. J. Pharmacol. 230, 53.
Tsukamoto, A. and Karneko, Y. 1993. Cell. Biol. Int. 17, 969.
Wong, W.L., et al. 1993. Biochem. J. 289, 71.
Glennon, M.C., et al. 1992. J. Biol. Chem. 267, 25568.
Xu, Y., et al. 1992. J. Neurochem. 59, 2224.
Mason, M.J., et al. 1991. J. Biol. Chem. 266, 20856.
Thastrup, O., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 2466.