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616400 Tranilast - CAS 53902-12-8 - Calbiochem

An anthranilic acid analog that acts as a potent inhibitor of VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis.

Tranilast - CAS 53902-12-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(3ʹ,4ʹ-Dimethoxycinnamoyl)anthranilic Acid

Primary Target: VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
53902-12-8C₁₈H₁₇NO₅

Products

Catalog NumberPackaging Qty/Pack
616400-10MG Plastic ampoule 10 mg
Description
OverviewAn anthranilic acid analog that acts as a potent inhibitor of VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis. Inhibits VEGF- and PMA-stimulated PKC activity in retinal capillary endothelial cells without affecting the VEGF binding or VEGF receptor phosphorylation. Also has antiallergic, anti-inflammatory, and antiproliferative properties. Induces Ca2+ mobilization in vascular smooth muscle.
Catalogue Number616400
Brand Family Calbiochem®
SynonymsN-(3ʹ,4ʹ-Dimethoxycinnamoyl)anthranilic Acid
References
ReferencesKoyama, S., et al. 1999. Br. J. Pharmacol. 127, 537.
Isaji, M., et al. 1998. Life Sci. 63, PL71.
Isaji, M., et al. 1997. Br. J. Pharmacol. 122, 1061.
Product Information
CAS number53902-12-8
ATP CompetitiveN
FormPale yellow solid
Hill FormulaC₁₈H₁₇NO₅
Chemical formulaC₁₈H₁₇NO₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetVEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSDG8731000
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
616400-10MG 04055977185683

Documentation

Tranilast - CAS 53902-12-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Tranilast - CAS 53902-12-8 - Calbiochem Certificates of Analysis

TitleLot Number
616400

References

Reference overview
Koyama, S., et al. 1999. Br. J. Pharmacol. 127, 537.
Isaji, M., et al. 1998. Life Sci. 63, PL71.
Isaji, M., et al. 1997. Br. J. Pharmacol. 122, 1061.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-May-2008 RFH
SynonymsN-(3ʹ,4ʹ-Dimethoxycinnamoyl)anthranilic Acid
DescriptionAn anthranilic acid analog that acts as a potent inhibitor of VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis. Also has antiallergic, anti-inflammatory, and antiproliferative properties. Induces Ca2+ mobilization in vascular smooth muscle.
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number53902-12-8
RTECSDG8731000
Chemical formulaC₁₈H₁₇NO₅
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (200 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
Toxicity Harmful
Merck USA index14, 9570
ReferencesKoyama, S., et al. 1999. Br. J. Pharmacol. 127, 537.
Isaji, M., et al. 1998. Life Sci. 63, PL71.
Isaji, M., et al. 1997. Br. J. Pharmacol. 122, 1061.