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616467 Transglutaminase 2 Inhibitor, ZDON - Calbiochem

A cell-permeable, peptide-based, irreversible inhibitor of transglutaminase 2 (TG2; IC₅₀ = 150 nM for recombinant TG2). Reacts with the active site cysteine of TG2.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Z-DON, 6-diazo-5-oxo-norleucine tetrapeptide, TG2 Inhibitor

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616467
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₃₁H₄₅N₇O₉

Products

Catalog NumberPackaging Qty/Pack
616467-5MG Glass bottle 5 mg
Description
OverviewA cell-permeable, peptide-based (Z- QVPL) irreversible inhibitor of transglutaminase 2 (TG2) (IC50 = 150 nM for recombinant TG2) that acts by reacting with the active site cysteine of TG2. Exhibits far less potency against TG1 and TG3. Shown to significantly increase PGC-1a and cytochrome c mRNA levels in Q7 and Q111 cells (~50 mM). Also shown to enhance cytochrome c promoter activity by 250% in Q111 cells. Exhibits protective effect in cells exposed to 3-nitropropionic acid and NMDA, however, it does not directly affect mitochondrial bioenergetics.
Catalogue Number616467
Brand Family Calbiochem®
SynonymsZ-DON, 6-diazo-5-oxo-norleucine tetrapeptide, TG2 Inhibitor
References
ReferencesMcConoughey, S. J., et al. 2010. EMBO Mol. Medicine. 2, 349.
Product Information
FormOff-white powder
Hill FormulaC₃₁H₄₅N₇O₉
Chemical formulaC₃₁H₄₅N₇O₉
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
616467-5MG 04055977185973

Documentation

Transglutaminase 2 Inhibitor, ZDON - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Transglutaminase 2 Inhibitor, ZDON - Calbiochem Certificates of Analysis

TitleLot Number
616467

References

Reference overview
McConoughey, S. J., et al. 2010. EMBO Mol. Medicine. 2, 349.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-April-2014 JSW
SynonymsZ-DON, 6-diazo-5-oxo-norleucine tetrapeptide, TG2 Inhibitor
DescriptionA cell-permeable, peptide-based (Z- QVPL) irreversible inhibitor of transglutaminase 2 (TG2) (IC50 = 150 nM for recombinant TG2) that acts by reacting with the active site cysteine of TG2. Exhibits far less potency against TG1 and TG3. Shown to significantly increase PGC-1a and cytochrome c mRNA levels in Q7 and Q111 cells (~50 mM). Also shown to enhance cytochrome c promoter activity by 250% in Q111 cells. Exhibits protective effect in cells exposed to 3-nitropropionic acid and NMDA, however, it does not directly affect mitochondrial bioenergetics.
FormOff-white powder
Chemical formulaC₃₁H₄₅N₇O₉
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesMcConoughey, S. J., et al. 2010. EMBO Mol. Medicine. 2, 349.