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108219 Tris(hydroxymethyl)aminomethane hydrochloride

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MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Trometamol, Aminomethylidine trimethanol, 2-Amino-2-hydroxymethyl-1.3-propanediol, TRIS-buffer

CAS #: 1185-53-1 EC Number: 214-684-5 Molar Mass: 157.60 g/mol Chemical Formula: C₄H₁₁NO₃*ClH Hill Formula: C₄H₁₁NO₃˙ ClH
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108219
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Overview

Replacement Information

Key Specifications Table

CAS #EC NumberHill FormulaChemical FormulaMolar Mass
1185-53-1214-684-5C₄H₁₁NO₃˙ ClHC₄H₁₁NO₃*ClH157.60 g/mol

Products

Catalog NumberPackaging Qty/Pack
1082191000 Plastic bottle 1 kg
1082191003 Plastic bottle 1 kg
1.08219.5000 Plastic bottle 5 kg
1082199010 Plastic drum 10 kg
1082199012 Bucket, plastic 12 kg
1082199013 Bucket, plastic 12 kg
1082199050 Plastic drum 50 kg
Description
Catalogue Number108219
SynonymsTrometamol, Aminomethylidine trimethanol, 2-Amino-2-hydroxymethyl-1.3-propanediol, TRIS-buffer
DescriptionTris(hydroxymethyl)aminomethane hydrochloride
References
Product Information
CAS number1185-53-1
EC number214-684-5
Hill FormulaC₄H₁₁NO₃˙ ClH
Chemical formulaC₄H₁₁NO₃*ClH
Molar Mass157.60 g/mol
HS Code2922 19 99
Structure formula ImageStructure formula Image
Quality LevelMQ500
Applications
Biological Information
Physicochemical Information
Density1.28 g/cm3 (20.2 °C)
Melting Point150.7 °C
pH value4.2 (100 g/l, H₂O, 20 °C)
Vapor pressure<0.1 hPa (50 °C)
Solubility561 g/l soluble
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Storage class10 - 13 Other liquids and solids
WGKWGK 1 slightly hazardous to water
Disposal3
Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C.
Safety Information
Product Usage Statements
Storage and Shipping Information
StorageStore at +15°C to +25°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Appearancewhite to almost white, crystalline powder
Assay (alkalimetric, calculated on dried substance)≥ 99.0 %
Identity (IR-spectrum)conforms
pH-value (0.5 mol/l, water)3.5 - 5.0
Melting point147 - 153 °C
UV-Absorption (230 nm; 10 %; 1 cm; water)≤ 0.1
UV-Absorption (260 nm; 10 %, 1 cm; water)≤ 0.06
UV-Absorption (280 nm; 10 %; 1 cm; water)≤ 0.06
UV-Absorption (300 nm; 10 %; 1 cm; water)≤ 0.02
UV-Absorption (400 nm; 10 %; 1 cm; water)≤ 0.01
Residual solvents (ICHQ3C) of class 2 (Methanol)≤ 3000 ppm
Residual solvents (ICHQ3C) of class 2 (Nitromethane)≤ 50 ppm
Residual solvents (ICHQ3C) of class 3 (Ethanol)≤ 5000 ppm
Residual solvents (ICHQ3C) of class 3 (Ethylmethylketon)≤ 5000 ppm
Other residual solvents (ICH Q3C)excluded by manufacturing process
Sulfated ash≤ 0.03
Loss on Drying (105°C)≤ 0.5
Endotoxins< 2.5
Total aerobic microbial count≤ 10²
Total yeast and mould count
≤ 10²
Salmonella spp.
absent in 10 g
E.coli
absent in 1 g
Staphylococcus aureus
absent in 1 g
Pseudomonas aeruginosa
absent in 1 g
Candida albicans
absent in 1 g
Bile tolerante gram negative bacteria
absent in 1 g
DNases (Exo- and endonucleases)
not detected
Proteases
not detected
RNases
not detected
Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
Total yeast and mould count
≤ 10²
Salmonella spp.
absent in 10 g
E.coli
absent in 1 g
Staphylococcus aureus
absent in 1 g
Pseudomonas aeruginosa
absent in 1 g
Candida albicans
absent in 1 g
Bile tolerante gram negative bacteria
absent in 1 g
DNases (Exo- and endonucleases)
not detected
Proteases
not detected
RNases
not detected
Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
Global Trade Item Number
Catalog Number GTIN
1082191000 04022536101811
1082191003 04027269196462
1.08219.5000 04022536532899
1082199010 04022536702742
1082199012 04027269285586
1082199013 04027269285593
1082199050 04054839392443

Documentation

Material Qualification Dossier

TitleVersion
6.0

Quality Management Dossier (Open Access)

Title

Operational Excellence Dossier

Title

Tris(hydroxymethyl)aminomethane hydrochloride SDS

Title

Safety Data Sheet (SDS) 

Tris(hydroxymethyl)aminomethane hydrochloride Certificates of Analysis

Product Number PackagingSpecificationLot Number
1082191000 Plastic bottlePDF Specification Document
1082191003 Plastic bottlePDF Specification Document
1.08219.5000 Plastic bottlePDF Specification Document
1082199010 Plastic drumPDF Specification Document
1082199012 Bucket, plasticPDF Specification Document
1082199013 Bucket, plasticPDF Specification Document
1082199050 Plastic drumPDF Specification Document

Certificates

Title