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14-922M TrkC, active

TrkC, active MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
14-922M
250 µg  Also available in 10μg size as catalog # 14-922 and in bulk as catalog # 14-922-K.
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Catalogue Number14-922M
Trade Name
  • Upstate
DescriptionTrkC, active
OverviewTrkC is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense
body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene.
References
Product Information
Presentation50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol
Quality LevelMQ300
Applications
Key Applications
  • Kinase Assay
Biological Information
SourceN-terminal GST-tagged and C-terminal 6His-tagged, recombinant, human TrkC amino acids 510-end, expressed by baculovirus in Sf21 insect cells
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Gene Symbol
  • TRKC
  • NTRK3
  • Trk-C
Purification MethodPurified using glutathione agarose followed by gel filtration.
Target Sub-FamilyTK
UniProt Number
Molecular Weight64 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by phosphorylation of GEEPLYWSFPAKKK
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C
Packaging Information
Material Size250 µg
Material PackageAlso available in 10μg size as catalog # 14-922 and in bulk as catalog # 14-922-K.
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
14-922M 04053252907890

Related Products & Applications

Alternative Packsize

Catalog Number Description
14-922 TrkC, active

Product Families

Kinase & Phosphatase Products

Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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Categories

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases