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662105 Ubiquitin E1 Inhibitor, PYR-41 - Calbiochem

Ubiquitin E1 Inhibitor, PYR-41, CAS 418805-02-4, is a cell-permeable, irreversible inhibitor of ubiquitin-activating enzyme E1 activity (IC50 less than 10 µM in cell-free E1 ubiquitination reactions).

Ubiquitin E1 Inhibitor, PYR-41 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(4-(5-Nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester, trihydrate, Ubiquitin-Activating Enzyme E1 Inhibitor, PYR-41

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662105
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₇H₁₃N₃O₇ • 3H₂O

Products

Catalog NumberPackaging Qty/Pack
662105-25MG Plastic ampoule 25 mg
Description
OverviewA cell-permeable pyrazone compound that irreversibly (presumably via covalent modification) inhibits ubiquitin-activating enzyme E1 activity (IC50 <10 µM in cell-free E1 ubiquitination reactions), while exhibiting little or no activity against E3, E2, or caspase enzymatic activity. Blocks ubiquitination-dependent protein degradation and other ubiquitination-mediated cellular activities. E1 inactivation by PYR-41 or other means has been shown to result in an overall elevation of sumoylation.
Catalogue Number662105
Brand Family Calbiochem®
Synonyms4-(4-(5-Nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester, trihydrate, Ubiquitin-Activating Enzyme E1 Inhibitor, PYR-41
References
ReferencesYang, Y., et al. 2007. Cancer Res. 67, 9472.
Product Information
FormDark purple solid
Hill FormulaC₁₇H₁₃N₃O₇ • 3H₂O
Chemical formulaC₁₇H₁₃N₃O₇ • 3H₂O
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationUbiquitin E1 Inhibitor, PYR-41, CAS 418805-02-4, is a cell-permeable, irreversible inhibitor of ubiquitin-activating enzyme E1 activity (IC50 less than 10 µM in cell-free E1 ubiquitination reactions).
Biological Information
Purity≥90% by HPLC (sum of two isomers)
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 22-24/25-36-45

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. At room temperature, compound will undergo ~1% decomposition per day.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
662105-25MG 04055977261196

Documentation

Ubiquitin E1 Inhibitor, PYR-41 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Ubiquitin E1 Inhibitor, PYR-41 - Calbiochem Certificates of Analysis

TitleLot Number
662105

References

Reference overview
Yang, Y., et al. 2007. Cancer Res. 67, 9472.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision09-March-2009 RFH
Synonyms4-(4-(5-Nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester, trihydrate, Ubiquitin-Activating Enzyme E1 Inhibitor, PYR-41
DescriptionA cell-permeable pyrazone compound that irreversibly (presumably via covalent modification) inhibits ubiquitin-activating enzyme E1 activity (IC50 <10 µM in cell-free E1 ubiquitination reactions), while exhibiting little or no activity against E3, E2, or caspase enzymatic activity. Blocks ubiquitination-dependent protein degradation and other ubiquitination-mediated cellular activities. E1 inactivation by PYR-41 or other means has been shown to result in an overall elevation of sumoylation.
FormDark purple solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₇H₁₃N₃O₇ • 3H₂O
Structure formulaStructure formula
Purity≥90% by HPLC (sum of two isomers)
SolubilityDMSO (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. At room temperature, compound will undergo ~1% decomposition per day.
Toxicity Irritant
ReferencesYang, Y., et al. 2007. Cancer Res. 67, 9472.