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672315 Ursolic Acid - CAS 77-52-1 - Calbiochem

A cell-permeable plant-derived pentacyclic triterpene acid that displays anti-inflammatory, immunomodulatory, and antitumor activities.

Ursolic Acid - CAS 77-52-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3β-Hydroxy-urs-12-en-28-oic acid, CG7, PTPN2/TCPTP Inhibitor II, SHP2 Inhibitor IV, PTP1B Inhibitor VII, PTP Inhibitor XXVII

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672315
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
77-52-1C₃₀H₄₈O₃

Products

Catalog NumberPackaging Qty/Pack
672315-50MG Glass bottle 50 mg
Description
OverviewA cell-permeable plant-derived pentacyclic triterpene acid that displays anti-inflammatory, immunomodulatory, and antitumor activities. Shown to inhibit the phosphatase activity of SHP2, PTP1B, and TCPTP (IC50 = 2.73, 3.08 and 3.33 µM, respectively) as well as induce IR autophosphorylation independent of its phosphatase inhibitory activity. Ursolic acid is also reported to inhibit NF-κB and STAT3 pathway activation in cancer cultures, resulting in enhanced sensitivity to chemotherapy agents and apoptotic cell death.
Catalogue Number672315
Brand Family Calbiochem®
Synonyms3β-Hydroxy-urs-12-en-28-oic acid, CG7, PTPN2/TCPTP Inhibitor II, SHP2 Inhibitor IV, PTP1B Inhibitor VII, PTP Inhibitor XXVII
References
ReferencesLi, Y., et al. 2010. Int. J. Cancer 127, 462.
Pathak, A.K., et al. 2007. Mol. Cancer Res. 5, 943.
Jung, S.H., et al. 2007. Biochem. J. 403, 243.
Zhang, W., et al. 2006. Biochim. Biophys. Acta 1760, 1505.
Shishodia, S., et al. 2003. Cancer Res. 63, 4375.
Product Information
CAS number77-52-1
FormWhite powder
Hill FormulaC₃₀H₄₈O₃
Chemical formulaC₃₀H₄₈O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥90% by GC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
672315-50MG 04055977184136

Documentation

Ursolic Acid - CAS 77-52-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Ursolic Acid - CAS 77-52-1 - Calbiochem Certificates of Analysis

TitleLot Number
672315

References

Reference overview
Li, Y., et al. 2010. Int. J. Cancer 127, 462.
Pathak, A.K., et al. 2007. Mol. Cancer Res. 5, 943.
Jung, S.H., et al. 2007. Biochem. J. 403, 243.
Zhang, W., et al. 2006. Biochim. Biophys. Acta 1760, 1505.
Shishodia, S., et al. 2003. Cancer Res. 63, 4375.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-December-2023 JSW
Synonyms3β-Hydroxy-urs-12-en-28-oic acid, CG7, PTPN2/TCPTP Inhibitor II, SHP2 Inhibitor IV, PTP1B Inhibitor VII, PTP Inhibitor XXVII
DescriptionA cell-permeable plant-derived pentacyclic triterpene acid that displays anti-inflammatory, immunomodulatory, and antitumor activities. Shown to inhibit the phosphatase activity of SHP2, PTP1B, and TCPTP (IC50 = 2.73, 3.08 and 3.33 µM, respectively) as well as induce IR autophosphorylation independent of its phosphatase inhibitory activity. Ursolic acid is also reported to inhibit NF-κB and STAT3 pathway activation in cancer cultures, resulting in enhanced sensitivity to chemotherapy agents and apoptotic cell death.
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
CAS number77-52-1
Chemical formulaC₃₀H₄₈O₃
Structure formulaStructure formula
Purity≥90% by GC
SolubilityDimethylformamide or DMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesLi, Y., et al. 2010. Int. J. Cancer 127, 462.
Pathak, A.K., et al. 2007. Mol. Cancer Res. 5, 943.
Jung, S.H., et al. 2007. Biochem. J. 403, 243.
Zhang, W., et al. 2006. Biochim. Biophys. Acta 1760, 1505.
Shishodia, S., et al. 2003. Cancer Res. 63, 4375.