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677181 Vincristine Sulfate, Apocynaceae sp. - CAS 2068-78-2 - Calbiochem

Indole alkaloid that binds to tubulin, inhibiting formation of microtubules.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Tubulin
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677181
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
2068-78-2C₄₆H₅₆N₄O₁₀ · H₂SO₄

Products

Catalog NumberPackaging Qty/Pack
677181-10MG Plastic ampoule 10 mg
Description
OverviewIndole alkaloid that binds to tubulin, inhibiting formation of microtubules. Depolymerizes microtubules. Induces increase in micronuclei and delays cell cycle progression. Anti-neoplastic agent. Induces apoptosis in human lymphoma cells by disrupting microtubules.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number677181
Brand Family Calbiochem®
References
ReferencesChan, M.W., et al. 1998. Cancer Biochem. Biophys. 16, 347.
Hanauske, A.R., et al. 1994. Eur. J. Cancer 30A, 1688.
Takano, Y., et al. 1993. Pathol. Res. Pract. 189, 187.
Product Information
CAS number2068-78-2
ATP CompetitiveN
FormWhite solid
Hill FormulaC₄₆H₅₆N₄O₁₀ · H₂SO₄
Chemical formulaC₄₆H₅₆N₄O₁₀ · H₂SO₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetTubulin
Purity≥98% by TLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSOH6340000
Safety Information
R PhraseR: 36/37/38-60-61

Irritating to eyes, respiratory system and skin.
May impair fertility.
May cause harm to the unborn child.
S PhraseS: 22-26-36/37/39-45

Do not breathe dust.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
677181-10MG 04055977260601

Documentation

Vincristine Sulfate, Apocynaceae sp. - CAS 2068-78-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Vincristine Sulfate, Apocynaceae sp. - CAS 2068-78-2 - Calbiochem Certificates of Analysis

TitleLot Number
677181

References

Reference overview
Chan, M.W., et al. 1998. Cancer Biochem. Biophys. 16, 347.
Hanauske, A.R., et al. 1994. Eur. J. Cancer 30A, 1688.
Takano, Y., et al. 1993. Pathol. Res. Pract. 189, 187.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-July-2017 JSW
DescriptionIndole alkaloid that binds to tubulin, inhibiting the formulation of microtubules. Depolymerizes microtubules. Induces an increase in the micronucleus and delays cell cycle progression. Antineoplastic agent. Induces apoptosis in human lymphoma cells by distributing microtubules.
FormWhite solid
CAS number2068-78-2
RTECSOH6340000
Chemical formulaC₄₆H₅₆N₄O₁₀ · H₂SO₄
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityH₂O (20 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C.
Toxicity Carcinogenic / Teratogenic
Merck USA index14, 9986
ReferencesChan, M.W., et al. 1998. Cancer Biochem. Biophys. 16, 347.
Hanauske, A.R., et al. 1994. Eur. J. Cancer 30A, 1688.
Takano, Y., et al. 1993. Pathol. Res. Pract. 189, 187.