681669 Sigma-AldrichWnt Antagonist I, IWR-1-endo - Calbiochem
Wnt Antagonist I, IWR-1-endo, is a cell-permeable inhibitor of TNKS1/PARP5a (IC₅₀ = 131 nM) & TNKS2/PARP5b (IC₅₀= 56 nM). Suppress Wnt-stimulated transcription activity (IC₅₀ = 180 nM).
More>> Wnt Antagonist I, IWR-1-endo, is a cell-permeable inhibitor of TNKS1/PARP5a (IC₅₀ = 131 nM) & TNKS2/PARP5b (IC₅₀= 56 nM). Suppress Wnt-stimulated transcription activity (IC₅₀ = 180 nM). Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: TNKS1/2 Inhibitor II, Wnt Pathway Inhibitor I, Inhibitor of Wnt Response-1, Tankyrase1/2 Inhibitor II
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Overview
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Key Specifications Table
| Empirical Formula |
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| C₂₅H₁₉N₃O₃ |
Products
| Catalog Number | Packaging | Qty/Pack | |
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| 681669-10MG | Plastic ampoule | 10 mg |
| Description | |
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| Overview | A cell-permeable p-imidobenzamidoquinoline, endo-diastereomer that is shown to inhibit the activity of TNKS1/PARP5a and TNKS2/PARP5b in in vitro auto-PARsylation assays (IC50 = 131 and 56 nM, respectively) and effectively suppress Wnt-stimulated transcription activity in L-Wnt-STF-based reporter assays (IC50 = 180 nM), while exhibiting little activity against PARP1 or PARP2 (IC50 >18.75 µM). Although both IWR-1-endo and XAV939 act as reversible Wnt pathway inhibitors and exhibit similar pharmacological effects both in vitro and in vivo, IWR-1-endo exerts its effect via interaction with Axin, while XAV939 binds TNKS directly. Also available as a 25 mM solution in DMSO (Cat. No. 504462). |
| Catalogue Number | 681669 |
| Brand Family | Calbiochem® |
| Synonyms | TNKS1/2 Inhibitor II, Wnt Pathway Inhibitor I, Inhibitor of Wnt Response-1, Tankyrase1/2 Inhibitor II |
| References | |
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| References | Chen, B., et al. 2009. Nature Chem. Biol. 5, 100. Huang, S.M., et al. 2009. Nature 461, 614. |
| Product Information | |
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| Form | Off-white solid |
| Hill Formula | C₂₅H₁₉N₃O₃ |
| Chemical formula | C₂₅H₁₉N₃O₃ |
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| Quality Level | MQ100 |
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| Purity | ≥95% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 681669-10MG | 04055977260274 |
Documentation
Wnt Antagonist I, IWR-1-endo - Calbiochem SDS
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Wnt Antagonist I, IWR-1-endo - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 681669 |
References
| Reference overview |
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| Chen, B., et al. 2009. Nature Chem. Biol. 5, 100. Huang, S.M., et al. 2009. Nature 461, 614. |