324517 Sigma-AldricheIF4E/eIF4G Interaction Inhibitor, 4EGI-1 - CAS 315706-13-9 - Calbiochem
eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, CAS 315706-13-9, is a cell-permeable compound that reversibly binds eIF4E (KD = 25 µM) and disrupts eIF4E/eIF4G complex formation.
More>> eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, CAS 315706-13-9, is a cell-permeable compound that reversibly binds eIF4E (KD = 25 µM) and disrupts eIF4E/eIF4G complex formation. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid, eIF4F Inhibitor I
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Overview
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Key Specifications Table
| CAS # | Empirical Formula |
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| 315706-13-9 | C₁₈H₁₂Cl₂N₄O₄S |
Products
| Catalog Number | Packaging | Qty/Pack | |
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| 324517-10MG | Plastic ampoule | 10 mg |
| Description | |
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| Overview | A cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; KD = 25 µM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation. Reported to downregulate the protein, but not mRNA, levels of c-Myc and Bcl-xL in Jurkat cells (8 h), leading to apoptotic cell death after prolonged exposure (24 h, IC50 = ~ 25 µM). Also available as a 25 mM solution in DMSO (Cat. No. 324519). |
| Catalogue Number | 324517 |
| Brand Family | Calbiochem® |
| Synonyms | 2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid, eIF4F Inhibitor I |
| References | |
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| References | Moerke, N. J., et al. 2007. Cell 128, 257. |
| Product Information | |
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| CAS number | 315706-13-9 |
| Form | Yellow solid |
| Hill Formula | C₁₈H₁₂Cl₂N₄O₄S |
| Chemical formula | C₁₈H₁₂Cl₂N₄O₄S |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications | |
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| Application | eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, CAS 315706-13-9, is a cell-permeable compound that reversibly binds eIF4E (KD = 25 µM) and disrupts eIF4E/eIF4G complex formation. |
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| Purity | ≥98% by HPLC (sum of two isomers) |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 324517-10MG | 04055977197327 |
Documentation
eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 - CAS 315706-13-9 - Calbiochem SDS
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eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 - CAS 315706-13-9 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 324517 |
References
| Reference overview |
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| Moerke, N. J., et al. 2007. Cell 128, 257. |
Citations
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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