Fmoc-azido Acids |
For the incorporation of differentially-protected amino groups within a peptide sequence, we offer derivatives bearing protecting groups cleavable with reagents ranging from mild acids, Pd(0), alpha-effect nucleophiles, and phosphines. Fmoc-azido acids are tools for Fmoc SPPS in which the side-chain amino group is unmasked by reduction. These derivatives can be coupled using standard activation methods. The azido group is stable to both TFA and piperidine, so they can be used in both solid phase and solution phase synthetic strategies. Thiols should be omitted from the TFA cleavage mixture as their use can lead to reduction of the azido group. Liberation of the amine group from the azide has been accomplished by reduction with phosphines, thiols, or Zn/AcOH.
| Product | Catalog number |
|---|---|
| (2S,3S)-Fmoc-Abu(3-N3)-OH |
852352 |
| Fmoc-L-γ-azidohomoalanine-OH | 852321 |
| Fmoc-L-azidolysine | 852326 |
| Fmoc-L-δ-azidonorvaline-OH | 852322 |
| cis-Fmoc.Pro(4.N3).OH | 852351 |
Related Resources
Learn of the latest developments and methods in peptide synthesis. Find detailed product information, protocols and applications.