DNA Damage
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DNA Damage & TUNEL Assays | Life Science Research | MilliporeSigma
DNA damage and TUNEL assays are used to examine DNA fragmentation in apoptosis to get some data about DNA damage as it is related to the apoptotic process. -
Nuclear Function | Life Science Research | MilliporeSigma
A Nuclear function is to be home of an entire genome that can physically fit inside the nucleus and to allow the cell to differentiate, divide, and endure environmental stresses while protecting its valuable genetic information. -
Amnis Imaging Flow Cytometers | Life Science Research | MilliporeSigma | DNA Damage and Repair
The ImageStream images and quantifies nuclear foci formed by DNA repair proteins and micronuclei formed during DNA damage. The powerful combination of quantitative image analysis and flow cytometry in a single platform creates exceptional new experimental capabilities. -
Cell Signaling Assays for Muse Cell Analyzer | Life Science Research | MilliporeSigma
Muse signaling assays were developed to give researchers a rapid, simple method for detecting the activation of key signaling pathways in cell populations. -
Amnis Imaging Flow Cytometers | Life Science Research | MilliporeSigma | Spot Counting
The ImageStream images and quantifies spots in cells in many applications such as nuclear foci, viral load, phagocytosis, and FISH. -
Apoptosis Assays | Life Science Research | MilliporeSigma
Apoptosis is the ability of tumor cells to elude programmed cell death. Antibodies and Assays are used in many steps of the apoptosis pathway such as: The detection process. -
Genomic instability | Life Science Research | MilliporeSigma
Learn about the environmental factors that can hinder DNA repair. There are many evidence linking genomic and epigenomic changes to disorders involving accelerated aging. Evidence points to general physiological stress and disrupted circadian. It is also possible that decreased DNA repair is also a symptom, not a cause, of aging. To investigate this possibility, researchers will need to examine changes in transcriptional regulators of repair genes, such as ncRNAs, hormones, and other chromatin modulators. -
Stem Cell Exhaustion | Life Science Research | MilliporeSigma
As we age, our stem cells eventually lose their ability to divide and we are unable to replace the stem cells that have migrated, differentiated, or died. As a result, we show outward symbols of aging. -
Telomere Attrition | Life Science Research | MilliporeSigma
Telomerase attrition expression is silenced in many adult cells, to curb rampant cell proliferation and tumorigenesis, and so telomeres get progressively shorter with age.