chromatin+antibody
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Histones and Histone Modifications | Life Science Research | MilliporeSigma
Histone modifications regulate DNA transcription, repair, recombination, and replication, and can alter local chromatin architecture. Understanding histone modifications is key to uncovering epigenetic mechanisms of gene regulation. MilliporeSigma grasps the complexity of this research and provides a growing line of kits, antibodies, and assays for studying histones and their modifications. MilliporeSigma offers over 600 validated antibodies, recombinant proteins, and kits to analyze histone and histone-variant phosphorylation, methylation, acetylation, ubiquitination, and citrullination-the most widely studied histone modifications in epigenetics today. -
Epigenetics & Nuclear Function Antibodies | Life Science Research | MilliporeSigma
Epigenetics describes heritable changes to chromatin that can influence gene function. As the basic mechanisms of these changes has become better understood, the influence of epigenetic regulation in development and disease has become a focus. -
DNA Methylation | Life Science Research | MilliporeSigma
DNA methylation is involved in the regulation of many cellular processes, including chromosome stability, chromatin structure, X chromosome inactivation, embryonic development, and transcription. DNA methylation occurs mainly at the 5' position of cytosine bases and is mediated by enzymes called DNA methyltransferases (DNMT). Regions of methylated DNA can be bound by a variety of methylated DNA binding proteins (MBD). -
UCOE® References - Mammalian Expression | Life Science Research | MilliporeSigma
Mammalian expression using ubiquitous chromatin opening element (UCOE) technology, prevents transgene silencing for consistent and high-level gene expression. -
Press Release: MilliporeSigma Introduces Magna ChIP® HiSens Chromatin Immunoprecipitation Kits
MilliporeSigma, today introduced Magna ChIP® HiSens chromatin immunoprecipitation kits for superior enrichment and detection of specific regions of chromatin-associated DNA. -
RIP | Life Science Research | MilliporeSigma
RNA-binding protein immunoprecipitation (RIP) is the RNA analog of the ChIP application (chromatin immunoprecipitation). It can be used to identify specific RNA molecules (of many types) associated with specific nuclear or cytoplasmic binding proteins. -
Magna ChIP | Life Science Research | MilliporeSigma
Magna ChIP kits permit a rapid ChIP experiment in a single day and an easy optimization for any target antibody. Available with either protein A or protein G and containing essential positive and negative controls to ensure high quality results. -
Press Release: MilliporeSigma Introduces Magna ChIP™ HT96 Kits for High-Throughput Chromatin Immunoprecipitation
MilliporeSigma, today introduced the Magna ChIP™ HT96 kit for high-throughput chromatin immunoprecipitation (ChIP). -
Antibodies to Acetylated and Deacetylated Proteins | Life Science Research | MilliporeSigma
We offer a selection of assay kits and antibodies to measure acetylation and deacetylation activity, helping to elucidate the relationship between chromatin modification pathways and gene regulation.