EMD Millipore Introduces Novel Clarisolve^® Depth Filters that Deliver Unmatched Speed and Efficiency for Single-Stage Clarification of Pretreated Feed Streams

• Provides fast and more efficient clarification of high density pretreated feed streams
• Enables processing in a significantly reduced footprint with reduced flushing requirements
• Eliminates the need for centrifugation
• Fully scalable from lab to process scale

September 17, 2013, Billerica, MA — EMD Millipore, the Life Science division of Merck KGaA, Darmstadt, Germany, today introduced the Clarisolve^® depth filter for single-stage clarification of pretreated feed streams. The Clarisolve^® depth filter is a novel clarification device with a gradient density structure specifically designed to the particle size distributions of pretreated feed streams.

Delivering improved volumetric capacity and reduced turbidity over any currently available depth filtration technologies, Clarisolve^® depth filters process pretreated feeds in a significantly reduced footprint without the need for the secondary stage of clarification. The use of Clarisolve^® depth filters eliminates the need for centrifugation which enables implementation of a fully single-use process train, and also considerably reduces the pre-use flushing requirements. This technology was developed to address the shortcomings of traditional downstream clarification approaches when processing high cell density and high-product titer cell cultures.

”Until now, higher titers coming from upstream bioreactors have posed a challenge to conventional approaches to clarification,” described Vin Donovan, Vice President of Biopharm Process Solutions, EMD Millipore. “With Clarisolve^® depth filters, our customers can now take full advantage of high density pretreated feed streams and improve overall process economics.”

EMD Millipore has also developed a cationic pDADMAC (poly diallyldimenthyl ammonium chloride) flocculation reagent targeted for biopharmaceutical applications which can be used as a pretreatment in combination with the Clarisolve^® depth filters. pDADMAC treatment, in combination with Clarisolve^® depth filters, provides an effective solution for harvesting high cell density cultures and can be easily incorporated into current clarification platforms.

Clarisolve^® filters are available from lab, to pilot, to process scale in the industry leading disposable Pod format.

For more information, please visit www.emdmillipore.com/clarisolve.

About EMD Millipore
EMD Millipore is the Life Science division of Merck KGaA, Darmstadt, Germany, offers a broad range of innovative, performance products, services and business relationships that enable our customers' success in research, development and production of biotech and pharmaceutical drug therapies. Through dedicated collaboration on new scientific and engineering insights, and as one of the top three R&D investors in the Life Science Tools industry, EMD Millipore serves as a strategic partner to customers and helps advance the promise of life science.

Headquartered in Billerica, Massachusetts, the division has around 10,000 employees, operations in 66 countries and 2012 revenues of €2.6 billion.