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196878 (±)-Bay K 8644 - CAS 93468-89-4 - Calbiochem

Overview

Key Specifications Table

CAS #Empirical Formula
93468-89-4C₁₆H₁₅F₃N₂O₄

Pricing & Availability

Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
196878-1MG
Limited Availability
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      196878-5MG
      Limited Availability
Limited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          Plastic ampoule 5 mg
          Price could not be retrieved
          Minimum Quantity is a multiple of
          Maximum Quantity is
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          Description
          OverviewSynthetic dihydropyridine derivative that acts as an active Ca2+ slow channel agonist in neuroendocrine, muscle, thyroid and other cell types. Prolongs single channel open time without affecting the close time. An L-type Ca2+ channel agonist. Composed of two optical isomers. The (-)-enantiomer has strong vasoconstrictive, positive inotropic, and Ca2+ agonistic properties, whereas the (+)-enantiomer has weakly vasodilating, negative inotropic, and Ca2+ antagonistic properties. The net effect of the racemic mix is that of the negative enantiomer. Promotes β-cell proliferation/regeneration.
          Catalogue Number196878
          Brand Family Calbiochem®
          Synonyms1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2ʹ-(trifluoromethyl)phenyl]-3-pyridinecarboxylic Acid Methyl Ester
          References
          ReferencesWang, W., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 1427.
          Weigl, L.G., et al. 2000. J. Physiol. 525 (pt. 2), 461.
          Vannier, C., et al. 1995. Am. J. Physiol. 268, L201.
          Bechem, M., and Hoffmann, H. 1993. Pflugers Arch. 424, 343.
          Triggle, D.J., and Rompe, D. 1989. Trends Pharmacol. Sci. 10, 507.
          Takasu, N., et al. 1987. Biochem. Biophys. Res. Commun. 143, 1107.
          Tagliatela, M., et al. 1986. Brain Res. 381, 356.
          Franckowiak, G., et al. 1985. Eur. J. Pharmacol. 114, 223.
          Product Information
          CAS number93468-89-4
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₁₆H₁₅F₃N₂O₄
          Chemical formulaC₁₆H₁₅F₃N₂O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Biological Information
          Primary TargetL-type Ca2+ channel
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 20 days at 4°C.
          Global Trade Item Number
          Catalog Number GTIN
          196878-1MG 04055977206609
          196878-5MG 04055977206616