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219330 β-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem

Overview

Key Specifications Table

CAS #Empirical Formula
108409-83-2C₁₃H₁₀Cl₂N₂O₄S

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219330-10MG
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      Description
      OverviewA cell-permeable sulfonamide compound that acts as a dual pathway inhibitor against Wnt/β-catenin (≥80% inhibition at 15 µM in β-catenin/Tcf-dependent cellular reporter assays) and PPARγ/δ (≥30% inhibition at 0.5 µM in PPRE cellular reporter assays) signalings. Although both FH535 and the structurally similar PPARγ-selective inhibitor GW9662 (Cat. No. 370700) inhibit coactivator/PPAR binding, only FH535 blocks β-catenin/PPARγ interaction and the antagonistic activity of FH535 does not involve the covalent modification of or non-covalent interaction with the PPAR ligand-binding site cystein residue that is crucial for GW9662 action.
      Catalogue Number219330
      Brand Family Calbiochem®
      SynonymsWnt Pathway Inhibitor IX, N-(2-Methyl-4-nitro)-2,4-dichlorosulfonamide
      References
      ReferencesHandeli, S., and Simon, J.A. 2008. Mol. Cancer Ther. 7, 521.
      Product Information
      CAS number108409-83-2
      FormYellow solid
      Hill FormulaC₁₃H₁₀Cl₂N₂O₄S
      Chemical formulaC₁₃H₁₀Cl₂N₂O₄S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥99% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalog Number GTIN
      219330-10MG 04055977202090