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565767 α-Secretase Substrate II, Fluorogenic - Calbiochem

An internally quenched fluorogenic peptide substrate containing the α-secretase cleavage site of β-Amyloid Precursor Protein (APP).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Ac-RE(EDANS)-VHHQKLVF-K(DABCYL)-R-OH

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565767
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Overview

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565767-1MG
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      Description
      OverviewAn internally quenched fluorogenic peptide substrate containing the α-secretase cleavage site of β-Amyloid Precursor Protein (APP). Shown to be a substrate for yapsin 2, a glycosyl-phosphatidylinositol-linked yeast aspartyl protease (Vmax/Km = 0.031 min-1). The cleavage is shown to occur at the Lys-Leu bond.
      Catalogue Number565767
      Brand Family Calbiochem®
      SynonymsAc-RE(EDANS)-VHHQKLVF-K(DABCYL)-R-OH
      References
      ReferencesKomano, H., et al. 1999. J. Biol. Chem. 274, 24431.
      Komano, H., et al. 1998. J. Biol. Chem. 273, 31648.
      Product Information
      ATP CompetitiveN
      FormRed solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₀₀H₁₄₄N₃₀O₂₀S
      Chemical formulaC₁₀₀H₁₄₄N₃₀O₂₀S
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetSubstrate containing the α-secretase cleavage site of β-Amyloid Precursor Protein (APP)
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Emission max.
      Excitation max.
      Peptide SequenceAc-Arg-Glu(EDANS)-Val-His-His-Gln-Lys-Leu-Val-Phe-Lys(DABCYL)-Arg-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      565767-1MG 04055977267754

      Documentation

      α-Secretase Substrate II, Fluorogenic - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      α-Secretase Substrate II, Fluorogenic - Calbiochem Certificates of Analysis

      TitleLot Number
      565767

      References

      Reference overview
      Komano, H., et al. 1999. J. Biol. Chem. 274, 24431.
      Komano, H., et al. 1998. J. Biol. Chem. 273, 31648.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-September-2008 RFH
      SynonymsAc-RE(EDANS)-VHHQKLVF-K(DABCYL)-R-OH
      DescriptionAn internally quenched fluorogenic peptide substrate that contains the α-secretase cleavage site of β-amyloid precursor protein (APP). Shown to be an effective substrate for yapsin-2, a glycosyl-phosphatidylinositol-linked aspartyl protease found in yeast (Vmax/Km = 0.031 min-1). The cleavage has been shown to occur at the Lys-Leu bond. Excitation max: ~340 nm; emission max: ~490 nm.
      FormRed solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₀₀H₁₄₄N₃₀O₂₀S
      Peptide SequenceAc-Arg-Glu(EDANS)-Val-His-His-Gln-Lys-Leu-Val-Phe-Lys(DABCYL)-Arg-OH
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKomano, H., et al. 1999. J. Biol. Chem. 274, 24431.
      Komano, H., et al. 1998. J. Biol. Chem. 273, 31648.