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164603 3-Nitropropionic acid - CAS 504-88-1 - Calbiochem

Overview

Key Specifications Table

CAS #Empirical Formula
504-88-1C₃H₅NO₄

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164603-50MG
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      Glass bottle 50 mg
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      Description
      OverviewA cell-permeable, irreversible inactivator (~3 mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme. Disrupts the blood-brain barrier and causes severe energy (ATP) impairment. Also replicates several pathophysiological symptoms of Huntington disease, including spontaneous choreiform and dystonic movements and degeneration of striatum in rodent models. Chronic administration of 3-NP (38 mg/kg/day) is shown to cause activation of c-Jun kinase in striatum.
      Catalogue Number164603
      Brand Family Calbiochem®
      Synonyms3-Nitropropionic acid, 3-NP, 3-NPA, 3NPA
      References
      ReferencesBeal, M., et al. 1993, J. Neurosci. 13, 4181.
      Pang, Z., et al. 1997, J. Neuroscience 17, 3064.
      Huang, L., et al. 2006, J. Bio. Chem. 281, 5965.
      Garcia, M., et al. 2002, J. Neurosci. 22, 2174.
      Kim, G. W., et al. 2003, J. Neurosci. 23, 8733.
      Product Information
      CAS number504-88-1
      FormLight yellow powder
      Hill FormulaC₃H₅NO₄
      Chemical formulaC₃H₅NO₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥97% by HPLC
      Safety Information
      R PhraseR: 25-36/37/38

      Toxic if swallowed.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalog Number GTIN
      164603-50MG 04055977207590