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ABE1329 Anti-Chromobox protein homolog 3 Antibody

This Anti-Chromobox protein homolog 3 antibody is validated for use in WB, IC;IP for the detection of Chromobox protein homolog 3.

Anti-Chromobox protein homolog 3 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Nuclear Receptors Gene Symbol: CBX3 UniProt Number: Q13185
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ABE1329
100 µg  
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      Overview

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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ICC, IPRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE1329
      DescriptionAnti-Chromobox protein homolog 3 Antibody
      Alternate Names
      • Chromobox protein homolog 3
      • HECH
      • Heterochromatin protein 1 homolog gamma
      • HP1 gamma
      • Modifier 2 protein
      Background InformationChromobox protein homolog 3, also known as Chromobox protein homolog 3 (HECH), Heterochromatin protein 1 homolog gamma (HP1 gamma), or Modifier 2 protein, and encoded by the gene name CBX3, is implied to be involved in transcriptional silencing in heterochromatin-like complexes. Chromobox protein homolog 3 recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Chromobox protein homolog 3 may contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Chromobox protein homolog 3 may also play a role in the formation of functional kinetochore through interaction with MIS12 complex proteins. Chromobox protein homolog 3 binds directly to CHAF1A and it has been shown to interact with LBR, INCENP, TRIM28/TIF1B, SUV420H1, SUV420H2, SP100, MIS12, DSN1, CBX5 via the chromoshadow domain, POGZ, CHAMP1, and ASXL1. Chromobox protein homolog 3 is phosphorylated by PIM1. Recent studies have implied that Chromobox protein homolog 3 is phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Chromobox protein homolog 3 antibody is validated for use in WB, IC;IP for the detection of Chromobox protein homolog 3.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      • Immunoprecipitation
      Application NotesImmunoprecipitation Analysis: 10 µg from a representative lot immunoprecipitated Chromobox protein homolog 3 in 500 µg of HeLa nuclear extract.
      Immunocytochemistry Analysis: 1.0 µg/mL from a representative lot detected Chromobox protein homolog 3 in HeLa cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to Chromo Domain 1 of human Chromobox protein homolog 3.
      EpitopeChromo Domain 1
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Bovine, Monkey, Mouse, Rat, Horse based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CBX3
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~22 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HeLa nuclear extract.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected Chromobox protein homolog 3 in 10 µg of HeLa nuclear extract.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      ABE1329 04055977117004

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies