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MAB1934 Anti-Fibronectin Antibody, cell binding peptide, clone 784A2A6

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MAB1934
500 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      Ch, HELISA, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB1934
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Fibronectin Antibody, cell binding peptide, clone 784A2A6
      References
      Product Information
      FormatPurified
      PresentationLiquid in 0.02M Phosphate buffer, 0.25M NaCl with 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Fibronectin Antibody, cell binding peptide, clone 784A2A6 detects level of Fibronectin & has been published & validated for use in ELISA & WB.
      Key Applications
      • ELISA
      • Western Blotting
      Application NotesELISA

      Microscopy

      Western blotting at 1-5 μg/mL

      Cellular Adhesion Studies

      Note: Dilution without addition of carrier protein may cause denautration or adherence of the antibody to the vial. Dilution into a 1% bovine serum albumin containing buffer is recommended.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenHuman plasma fibronectin.
      Epitopecell binding peptide
      Clone784A2A6
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityReacts with the 11kd cell adhesive fragment and weakly inhibits cell binding to fibronectin (fibronectin mediated cell adhesion).
      IsotypeIgG1
      Species Reactivity
      • Chicken
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined.
      Gene Symbol
      • FN1
      • DKFZp686H0342
      • DKFZp686I1370
      • MSF
      • CIG
      • LETS
      • DKFZp686O13149
      • FN
      • DKFZp686F10164
      • FINC
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P02751 # Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Interaction with TNR mediates inhibition of cell adhesion and neurite outgrowth (By similarity).
      SIZE: 2386 amino acids; 262607 Da
      SUBUNIT: Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1, AMBP, TNR, LGALS3BP and COL13A1.
      SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
      TISSUE SPECIFICITY: Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine.DEVELOPMENTAL STAGE: Ugl-Y1, Ugl-Y2 and Ugl-Y3 are present in the urine from 0 to 17 years of age.
      PTM: Sulfated.
      SIMILARITY: SwissProt: P02751 ## Contains 12 fibronectin type-I domains. & Contains 2 fibronectin type-II domains. & Contains 16 fibronectin type-III domains.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C for up to 6 months in undiluted aliquots
      Packaging Information
      Material Size500 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      MAB1934 04053252665707

      Documentation

      Anti-Fibronectin Antibody, cell binding peptide, clone 784A2A6 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Fibronectin Antibody, cell binding peptide, clone 784A2A6 Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-HUMAN PLASMA FIBRONECTIN CELL BINDING PEPTIDE (CBP) MONOCLONAL ANTIBODY - 2352376 2352376
      MOUSE ANTI-HUMAN PLASMA FIBRONECTIN -2714466 2714466
      MOUSE ANTI-HUMAN PLASMA FIBRONECTIN -2779776 2779776
      MOUSE ANTI-HUMAN PLASMA FIBRONECTIN CELL BINDING PEPTIDE (CBP) - 3700485 3700485
      MOUSE ANTI-HUMAN PLASMA FIBRONECTIN CELL BINDING PEPTIDE (CBP) - 4068668 4068668
      MOUSE ANTI-HUMAN PLASMA FIBRONECTIN CELL BINDING PEPTIDE (CBP) MONOCLONAL ANTIBODY 2874605
      MOUSE ANTI-HUMAN PLASMA FIBRONECTIN CELL BINDING PEPTIDE (CBP) MONOCLONAL ANTIBODY 2925710

      References

      Reference overviewPub Med ID
      Covalent grafting of fibronectin onto plasma-treated PTFE: influence of the conjugation strategy on fibronectin biological activity.
      Karine Vallières,Eric Petitclerc,Gaétan Laroche
      Macromolecular bioscience  7  2007

      Show Abstract
      17457945 17457945
      Modulating cell adhesion and spreading by control of FnIII7-10 orientation on charged self-assembled monolayers (SAMs) of alkanethiolates.
      Hua Wang, Yi He, Buddy D Ratner, Shaoyi Jiang
      Journal of biomedical materials research. Part A  77  672-8  2006

      Show Abstract
      16514600 16514600
      Tumor-driven paracrine platelet-derived growth factor receptor alpha signaling is a key determinant of stromal cell recruitment in a model of human lung carcinoma.
      Tejada, ML; Yu, L; Dong, J; Jung, K; Meng, G; Peale, FV; Frantz, GD; Hall, L; Liang, X; Gerber, HP; Ferrara, N
      Clinical cancer research : an official journal of the American Association for Cancer Research  12  2676-88  2006

      Show Abstract
      16675559 16675559
      Internalization of antibodies by endothelial cells via fibronectin implicating a novel mechanism in lupus nephritis.
      Fujii, H; Nakatani, K; Arita, N; Ito, MR; Terada, M; Miyazaki, T; Yoshida, M; Ono, M; Fujiwara, T; Saiga, K; Ota, T; Ohtani, H; Lockwood, M; Sasaki, T; Nose, M
      Kidney international  64  1662-70  2003

      Show Abstract
      14531798 14531798

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      Product Families

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies