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MABS807 Anti-IKBKB, clone 10A2 Antibody

Anti-IKBKB, clone 10A2 Antibody is an antibody against IKBKB for use in Western Blotting.

Anti-IKBKB, clone 10A2 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Developmental Signaling Gene Symbol: IKBKB, IKKB UniProt Number: O14920
MABS807
100 µL  
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      Overview

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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMAscitesMonoclonal Antibody
      Description
      Catalogue NumberMABS807
      Replaces04-366
      DescriptionAnti-IKBKB, clone 10A2 Antibody
      Alternate Names
      • Inhibitor of nuclear factor kappa-B kinase subunit beta
      • I-kappa-B-kinase beta
      • IKK-B
      • IKK-beta
      • IkBKB
      • IKBKB
      Background InformationInhibitor of kappa light polypeptide gene enhancer in B-cells (IKBKB), also known as kinase beta or IKK2/IKKB, is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1. Once activated, IKK-beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK-beta activity can also be regulated by MEKK-1.
      References
      Product Information
      FormatAscites
      PresentationMouse monoclonal IgG1ascitic fluid containing 0.03% sodium azide.
      Quality LevelMQ300
      Applications
      ApplicationAnti-IKBKB, clone 10A2 Antibody is an antibody against IKBKB for use in Western Blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenPurified recombinant fragment of IKBKB expressed in E. Coli.
      Clone10A2
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • IKBKB
      • IKKB
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~87 and ~26 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in truncated IKBKB recombinant protein and K562 cell lysate.

      Western Blotting Analysis (WB): A 1:500-2,000 dilution of this antibody detected IKBKB in truncated IKBKB recombinant protein and K562 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      MABS807 04055977172188

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies