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ABS810 Anti-IKK beta Antibody

This Anti-IKK beta Antibody is validated for use in Western Blotting_x000D_ and Immunocytochemistry for the detection of IKK beta.

Anti-IKK beta Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Developmental Signaling Gene Symbol: IKBKB, IKKB UniProt Number: O14920
ABS810
100 μg  
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      Overview

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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ICCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABS810
      Replaces04-366
      DescriptionAnti-IKK beta Antibody
      Alternate Names
      • Inhibitor of nuclear factor kappa-B kinase subunit beta
      • I-kappa-B-kinase beta
      • IKK-B
      • IKK-beta
      • IkBKB
      Background InformationIKK-beta (I-Kappa-B kinase-beta) is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquitination. IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1. Once activated, IKK-beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK-beta activity can also be regulated by MEKK-1.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing PBS (pH 7.2) with 0.02% sodium azide.
      Quality LevelMQ300
      Applications
      ApplicationThis Anti-IKK beta Antibody is validated for use in Western Blotting_x000D_ and Immunocytochemistry for the detection of IKK beta.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis (ICC): 10 μg/mL from a representative lot detected IKK beta in HeLa cells.
      Biological Information
      ImmunogenIKK beta antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human IKK beta (Genbank accession NoO14920), which differs from corresponding murine sequence by one amino acid.
      EpitopeNear C-terminus
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • IKBKB
      • IKKB
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~88 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Jurkat whole cell lysate.

      Western Blotting Analysis (WB): A 1:500 dilution of this antibody detected IKK beta in Jurkat whole cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      ABS810 04055977174687

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies